Dr. M. Nasir Hayat Malik

PROFILE SUMMARY

Dr. Malik completed PhD. degree in Pharmacology from Medical School Hannover, Germany in 2019. Dr. Malik worked at different positions in retail pharmaceutical sector and academia. Dr. Malik has broad research interests in the areas of pharmacology. His research interests include identification and development of new treatment options for chronic diseases like arthritis, liver fibrosis, atherosclerosis and cancers specially hepatocellular carcinoma. He authored several research papers in ISI-impact factor journals of national and international repute. Dr. Malik is the lifetime member of Punjab Pharmacy Council, Pakistan.

QUALIFICATION
PhD	Pharmacology	Medical School Hannover, Hannover, Germany	2019
MPhil	Pharmacology	University of Sargodha, Sargodha, Pakistan	2011
Pharm.D.	Pharmacy	University of the Punjab, Lahore, Pakistan	2009

TEACHING EXPERIENCE
Assistant Professor	Capital University of Science and Technology (CUST), Islamabad	Since – 2023
Assistant Professor	Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan	2019 – 2023
Assistant Professor	Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan	2019 – 2023
PostDoc Fellow	TWINCORE, Hannover, Germany	2019
Demonstrator/Teaching Assistant	Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan	2009 – 2013

INDUSTRIAL EXPERIENCE
Retail Pharmacist	Doctor Awan Chemist Pharmacy, Jauharabad, Pakistan.	2009 – 2014

MEMBERSHIP OF PROFESSIONAL BODIES
Member	Punjab Pharmacy Council, Lahore, Pakistan

HONORS & AWARDS
1.	Won Gold medal in M.Phil Pharmacology from University of Sargodha
2.	Won HEC/DAAD overseas scholarship for the duration of four years (2014-2018)
3.	Won HZI, Braunschweig, Germany scholarship for the duration of 1.5 years (2018-2019)
4.	Won travel grant for prestigious “Onassis Summer School, Greece”. Participated in lecture series on Eukaryotic transcription and its regulation (16-20 July, 2018)

RESEARCH AREAS/ INTERESTS

Pharmacological and Toxicological Evaluation
Biomarkers Identification
Drug Designing and Development
Gene Editing

JOURNAL PUBLICATIONS
1.	W. Younis, M. N.H. Malik. “Pulegone prevents hypertension through activation of muscarinic receptors and cyclooxygenase pathway in L-NAME induced hypertensive rats”. Cardiovascular Therapeutics Journal, 2023
2.	G. Kamran, H. A. A. Kharl, M. N. H. Malik, et al. “Novel mannich-based derivative of 2-mercaptobenzimidazole (AK7): a new candidate for the treatment of inflammatory arthritis owing to its NF-κB1 inhibitory potential”, Naunyn-Schmiedeberg’s Archives of Pharmacology, 2022
3.	R. Shabbir, M. N. H. Malik, M. Zaib, Alamgeer, S. Jahan, M. T. Khan. “Amino acid conjugates of 2-mercaptobenzimidazole ameliorates high fat diet induced hyperlipidemia in rats via attenuation of HMGCR, APOB and PCSK9”, ACS Omega, vol. 7, no. 44, pp. 40502–40511, 2022
4.	H. M. Bilal, A. Sharif, M. N. H. Malik, H. M. Zubair. “Aqueous ethanolic extract of Adiantum incisum forssk. protects against type 2 diabetes mellitus via attenuation of α-amylase and oxidative stress”. ACS Omega, vol. 7, no. 42, pp. 37724–37735, 2022
5.	M. H. Mahnashi, T. Ahmad, Alamgeer, M. N. Mushtaq, M. N. H. Malik, M. Ahmed, A. Javed, M. M. Jalal, M. A. Altayar, A. Albloshi. “Investigation of the cardiac depressant effect of Caralluma tuberculata N.E.Br on isolated rabbit heart”. Tropical Journal of Pharmaceutical Research, vol. 21, no. 10, pp. 2125-2130, 2022
6.	U. Shabbir, I. Anjum, M. N. Mushtaq, M. N. H. Malik, S. Ismail, J. Javed, S. Noreen, A. Pervaiz, A. Tariq, M. Wazir, Z. Islam, M. Majid. “Uroprotective and hepatoprotective potential of Anagallis arvensis against the experimental animal model”. Journal of Tropical Medicine, 7241121, 2022
7.	S, Irshad, I. Anjum, M. N. Mushtaq, K. Barkat, M. N. H. Malik, M. A. Raza, M. Zubair. “Anti-Inflammatory, analgesic and anti-pyretic activity of Fagonia bruguieri DC in rats”. Pakistan Journal of Pharmaceutical Sciences, vol. 35, no, 4, pp.1211-1215, 2022
8.	S. F. H. Waqas, A. Sohail, A. H. H. Nguyen, A. Usman, T. Ludwig, A. Wegner, M. N. H. Malik, S. Schuchardt, R. Geffers, M. Winterhoff, S. Merkert, R. Olmer, N. Lachmann, F. Pessler. “ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives”. Clinical and Translational Medicine, vol. 12, no. 7, pp. e931, 2022
9.	A. M. Zubair, M. N. H. Malik, W. Younis, M. A. H. Malik, S. Jahan, I. Ahmed, A. Yuchi, M. N. Mushtaq, R. Tahir, M. B. Sarwar, M. Roman, A. A. Khan, M. N. Tahir, M. T. Khan, H. A. A. Kharl, G. Kamran, A. A. Albegali, A. Imran. “Novel acetamide derivatives of 2-aminobenzimidazole prevent inflammatory arthritis in rats via suppression of pro-inflammatory mediators”. Inflammaopharmacology, vol. 30, no. 3, pp. 1005-1019, 2022
10.	M. Fatima, I. Anjum, A. Abdullah, S. Z. Abid, M. N. H. Malik. “Boswellic acids, pentacyclic triterpenes, attenuate oxidative stress, and bladder tissue damage in cyclophosphamide-induced cystitis”. ACS Omega, vol. 7, no. 16, pp. 13697–13703, 2022
11.	S. Aslam, W. Younis, M. N. H. Malik, S. Jahan, Alamgeer, A. M. Uttra, M. U. Munir, M. Roman. “Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays. Inflammaopharmacology, vol. 30, no. 3, pp. 945-959, 2022.
12.	M. N. H. Malik, S. F. Waqas, J. Zeitvogel, J. Cheng, R. Geffers, Z. A. Gouda, A. M. Elsaman, A. R. Radwan, M. Schefzyk, P. Braubach, B. Auber, R. Olmer, M. Müsken, L. M. Roesner, G. Gerold, S. Schuchardt, S. Merkert, U. Martin, F. Meissner, T. Werfel, F. Pessler. “Congenital deficiency reveals critical role of ISG15 in skin homeostasis”. Journal of Clinical Investigation, vol. 132, no. 3, pp. e141573, 2022
13.	M. N. H. Malik. “ISG15 deficiency promotes skin ulcerations and viral resistance in humans”. Medizinische Hochschule, Hannover, Germany, 2022
14.	S. Merkert, M. C. Jaboreck, L. Engels, M. N. H. Malik, G. Göhring, F. Pessler, U. Martin, R. Olmer. Generation of two human ISG15 knockout iPSC clones using CRISPR/Cas9 editing”. Stem Cell Research, vol. 50, pp. 102135, 2020
15.	M. Martin-Fernandez, M. Bravo García-Morato, C. Gruber, S. Murias Loza, M. N. H. Malik, F. Alsohime, A. Alakeel, R. Valdez, S. Buta, G. Buda, M. A. Marti, M. Larralde, B. Boisson, M. Feito Rodriguez, X. Qiu, M. Chrabieh, M. Al Ayed, S. Al Muhsen, J. V. Desai, E. M. N. Ferre, S. D. Rosenzweig, B. Amador-Borrero, L. Y. Bravo-Gallego, R. Olmer, S. Merkert, M. Bret, A. K. Sood, A. Al-Rabiaah, M. H. Temsah, R. Halwani, M. Hernandez, F. Pessler, J. L. Casanova, J. Bustamante, M. S. Lionakis, D. Bogunovic. “Systemic type I IFN inflammation in human ISG15 deficiency leads to necrotizing skin lesions”. Cell Reports, vol. 31, no. 6, pp. 107633, 2020
16.	R. Olmer, L. Engels, A. Usman, S. Menke, M. N. H. Malik, F. Pessler, G. Göhring, D. Bornhorst, S. Bolten, S. Abdelilah-Seyfried, T. Scheper, H. Kempf, R. Zweigerdt, U. Martin. “Differentiation of human pluripotent stem cells into functional endothelial cells in scalable suspension culture”. Stem Cell Reports, vol. 8, no. 5, pp. 1657-1672, 2018
17.	S. Börchers, R. Babaei, C. Klimpel, J. Duque Escobar, S. Schröder, R. Blume, M. N. H. Malik, E. Oetjen. “TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT”. Naunyn-Schmiedeberg’s Archives of Pharmacology, vol. 390, no. 8, pp. 813-825, 2017
18.	Alamgeer, M. N. Mushtaq, S. Bashir, I. Ullah, S. Karim, M. Rashid, M. N. H. Malik, H. Rashid. “Comparative hypoglycemic activity of different fractions of Thymus serpyllum L. in alloxan induced diabetic rabbits”. Pakistan Journal of Pharmaceutical Sciences, vol. 29, pp. 1483-1488, 2016
19.	Alamgeer, A. Q. Khan, T. Ahmad, M. N. Mushtaq, M. N. H. Malik, H. Naz, H. Ahsan, H. Asif, N. Noor, M. S. U. Rahman, U. Dar, M. Rashid. “Phytochemical analysis and cardiotonic activity of methanolic extract of Ranunculus Muricatus Linn. in isolated rabbit heart”. Acta Poloniae, vol. 73, no. 4, pp. 949-954, 2016
20.	Alamgeer, M. N. H. Malik, S. Bashir, I. U. Khan, S. Karim, M. N. Mushtaq, H. U. Khan, M. Rashid, H. Naz, S. Samreen. “Cardiotonic and vasoconstriction effects of aqueous methanolic extract of Paspalidium flavidum L”. Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 2, pp. 437-441, 2015
21.	T. Ahmad, M. N. H. Malik, M. N Mushtaq. “Evaluation of antihypertensive effect of aqueous methanol extract of Caralluma tuberculata N.E.Br in sprauge dawley rats”. Tropical Journal of Pharmaceutical Research, vol. 14, no. 3, pp. 455-462, 2015
22.	Alamger, U. Mazhar, M. N. Mushtaq, H. U. Khan, S. Maheen, M. N. Malik, T. Ahmad, F. Latif, N. Tabassum, A. Q. Khan, H. Ahsan, W. Khan, I. Javed, H. Ali. “Evaluation of anti-inflammatory, analgesic and antipyretic activities of Thymus serphyllum Linn. in mice”. Acta Poloniae Pharmaceutica, vol. 72, no. 1, pp. 113-118, 2015
23.	A. Erum, S. Bashir, S. Saghir, U. R. Tulain, U. Saleem, M. Nasir, F. Kanwal, M. N. H. Malik. “Acute toxicity studies of a novel excipient arabinoxylan isolated from Ispaghula (Plantago ovata) husk”. Drug and Chemical Toxicology, vol. 38, pp. 300-305, 2014
24.	Alamgeer, M. S. Akhtar, Q. Jabeen, S. Bashir, M. N. H. Malik, S. Karim, M. N. Mushtaq, S. Rasool, F. Latif, N. Tabbasum, A. Q. Khan, H. Ahsan, W. Khan, I. Javed. “Possible mechanism of cardiac depressant activity of Berberis orthobotrys roots in isolated rabbit heart”. Acta Poloniae Pharmaceutica, vol. 71, no. 4, pp. 667-675, 2014
25.	Alamgeer, M. S. Akhtar, Q. Jabeen, H.U. Khan, S. Maheen, Haroon-Ur-Rash, S. Karim, S. Rasool, M. N. H. Malik, K. Khan. “Pharmacological evaluation of antihypertensive effect of aerial parts of Thymus linearis benth”. Acta Poloniae Pharmaceutica, vol. 71, no. 4, pp. 677-682, 2014
26.	M. S. Akhtar, S. Bashir, M. N. H. Malik, R. Manzoor. “Cardiotonic activity of methanolic extract of Saussurea lappa Linn roots”. Pakistan Journal of Pharmaceutical Sciences, vol. 26, no. 6, pp. 1197-1201, 2013
27.	A. Alamgeer, M. S. Akhtar, M. N. H. Malik. “Antihypertensive activity of aqueous-methanol extract of Berberis orthobotrys Bien Ex Aitch in rats”. Tropical Journal of Pharmaceutical Research, vol. 12, pp. 393-399, 2013
28.	H. Khan, S. Maheen, Alamgeer, A. Mahmood, R. M. Sarfaraz, M. N. H. Malik. “Determinants of Increasing Trend of Self-Medication in a Pakistani Community”. Tropical Journal of Pharmaceutical Research, vol. 13, no. 3, pp. 437-443, 2014
29.	Alamgeer, M. Rashid, M. N. H. Malik, S. Bashir. “Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits”. Bangladesh Journal of Pharmacology, vol. 8, pp. 186-193, 2013
30.	Alamgeer, M. N. H. Malik, M. N. Mushtaq. “Evaluation of diuretic activity of Paspalidium flavidum in rats”. Bangladesh Journal of Pharmacology, vol. 8, pp. 177-180, 2013
31.	Alamgeer, M. Rashid, M. N. H. Malik, M. N. Mushtaq. “Pharmacological evaluation of antidiabetic effect of ethyl acetate extract of Teucrium stocksianum Boiss in alloxan-induced diabetic rabbits”. The Journal of Animal and Plant Sciences, vol. 23, pp. 436-439, 2013
32.	Alamgeer, S. Bashir, M. S. Akhtar, M. N. H. Malik, M. N. Mushtaq. “Antihypertensive and toxicity studies of aqueous methanolic extract of Mentha longifolia L”. The Journal of Animal and Plant Sciences, vol. 23, pp. 1622-1627, 2013
33.	Alamgeer, T. Ahmad, M. N. H. Malik, M. N. Mushtaq. “Ethnomedicinal Survey of plants of Valley Alladand Dehri, Tehsil Batkhela, District Malakand, Pakistan”. International Journal of Basic Medical Sciences and Pharmacy, vol. 3, pp. 23-32, 2013
34.	Alamgeer, M. Rashid, T. Ahmad, M. N. H. Malik, M. N. Mushtaq. “Acute toxicity study and effect of Teucrium stocksianum boiss on blood glucose level and weight of glucose treated mice”. International Journal of Basic Medical Sciences and Pharmacy, vol. 3, pp. 13-16, 2013
35.	Alamgeer, M. N. Mushtaq, M. Rashid, T. Ahmad, M. N. H. Malik. “Evaluation of Hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice”. International Journal of Basic Medical Sciences and Pharmacy, vol. 3, pp. 33-36, 2013
36.	M. N. H. Malik, Alamgeer, U. Salma, A. Qayyum, S. Samreen. “Phytochemical analysis and cardiac depressant activity of aqueous methanolic extract of Morus nigra L. fruit”. Journal of Applied Pharmaceutical Science, vol. 2, pp. 039-041, 2012
37.	Alamgeer, M. N. Mushtaq, S. Bashir, M. Rashid, M. N. H. Malik. “Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn in alloxan-induced diabetic rabbits”. The African Journal of Pharmacy and Pharmacology, vol. 6, pp. 2845-2850, 2012
38.	Alamgeer, M. N. H. Malik, M. N. Mushtaq, S. Bashir, M. Rashid.” Evaluation of some central nervous system (CNS) activites of aqueous methanolic extract of Paspalidium flavidum Linn”. Journal of Medicinal Plants Research, vol. 6, pp. 3222-3227, 2012.

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