This course from pharmaceutical chemistry domain provides a comprehensive overview of the key concepts in organic chemistry. Course will comprise on the basic of organic chemistry and eventually with more emphasis on Organic molecules that are pharmaceutically important. Course will also cover mechanism of reactions involved in the organic chemistry. It aims to explain the functional groups of organic chemistry which play important role in synthesis of lead molecules and candidate drugs.
COURSE LEARNING OUTCOMES (CLO)
CLO: 1. Comprehend the fundamental principles and functional groups of organic chemistry.
CLO: 2. Explain organic reactions and their mechanisms
CLO: 3. Apply the basic concepts of organic reactions to understand the synthesis of drugs.
- BASIC CONCEPTS:
- Chemical Bonding and concept of Hybridization. Conjugation, Resonance (Mesomerism), Hyperconjugation, Aromaticity. Nomenclature of Organic Compounds. Inductive effect, Electromeric effect, Hydrogen bonding, Steric effect, Effect of structure on reactivity of compounds, Tautornerism of Carbonyl Compounds
- Stereoisomerism, optical isomerism; Molecules with more than one chiral center, Geometrical isomerism, Resolution of racemic mixture, Conformational analysis.
- Alkane, Alkenes, Alkynes, Aromatic compounds
- Alkyl halide, Alcohol, phenols, ethers, amines
- Ketones, Aldehydes
- Acids, Esters, Amides and derivative