## COURSE OBJECTIVES

This course presents the basic concepts and principles of biopharmaceutics and pharmacokinetics. The necessary mathematical expressions needed to characterize the absorption, distribution, metabolism, and excretion of drugs will be discussed with respect to routes of administration. Parameters that influence pharmacokinetic and therapeutic outcomes of the most common drug regimens will be emphasized. In addition, this course highlights some recent models i.e. compartmental models, their mathematical backbone and their relation to logical conclusions of drug time course in the body.

### COURSE LEARNING OUTCOMES (CLO)

CLO: 1. To describe the general principles of biopharmaceutics and pharmacokinetic
CLO: 2. To illustrate mechanism, methodologies and mathematical approaches described the fate of drug
CLO: 3. To apply knowledge of biopharmaceutics in different compartmental models and multiple dosing regimen

## COURSE CONTENTS

1 Construction of a calibration curve between absorbance and drug concentration
2 Understanding the use of semilogrithmic graph for plotting and analyzing the pharmacokinetic data
3 Determination of area under the curve (AUC) of the given data by trapezoidal method
4 Determination of area under the curve (AUC) of the given data by square counting method
5 Determination of area under the curve (AUC) of the given data by cutting and weighing method
6 Comparison of dissolution profile of a tablet formulation with commercially available reference formulation by using USP dissolution apparatus
7 Determination of order of kinetics for the given data sets using graphical and equation method
8 Determination of elimination rate constant “k” from urinary excretion data using sigma minus method
9 Determination of elimination rate constant “k” from urinary excretion data using rate method
10 Determination of pharmacokinetic parameters of drug using one compartment model after extravascular (oral) administration
11 Determination of pharmacokinetic parameters of a drug using two compartment model after extravascular (oral) administration
12 Compute pharmacokinetic parameters for a drug assuming one compartment model after IV infusion
13 Compute pharmacokinetic parameters for a drug assuming two compartment model after IV infusion
14 Calculation of absorption rate constant after oral drug administration using Wagner Nelson method
15 Calculation of tissue drug concentration from plasma data using Riegelman-Loo method
16 Calculation of pharmacokinetic parameters for oral data using non- compartmental approach
17 Calculation of pharmakinetic parameters of drug assuming saturation kinetics