Dr-Erum

Dr. Erum Dilshad

Associate Professor
PROFILE SUMMARY

Her research is focused on Nanobiotechnology, producing metallic nanoparticles by chemical and biological methods involving a green chemistry approach. She evaluates these metallic nanoparticles for their anticancer properties against cancer cell lines, including breast and liver cancer. Research also involves producing both medicinal and edible crops transgenics to enhance secondary metabolites and tolerance against biotic and abiotic stress along with their phytochemical analysis. Furthermore, her research is focused on computer-aided drug designing and screening biomolecules for their activities and effectiveness against various ailments, including cancer. She has been enlisted in AD World Scientist Ranking and as a Productive Scientist of Pakistan in 2016 and 2017, under age 40 by the Pakistan Council for Science and Technology Pakistan (PCST). To date, she has a significant number of ISI-indexed publications, and the total impact factor is 100. She has authored 10 book chapters with internationally recognized publishers and a complete book with Bentham Publishers.

QUALIFICATION
Ph.D Biochemistry/Plant Biotechnology Quaid-i-Azam University Islamabad 2016
M.phil Biochemistry/Molecular Biology Quaid-i-Azam University Islamabad 2010
M.Sc Biochemistry Quaid-i-Azam University Islamabad 2008
TEACHING EXPERIENCE
Associate Professor Capital University of Science and Technology (CUST), Islamabad Since – 2023
Assistant Professor Capital University of Science and Technology (CUST), Islamabad 2016 – 2022
INDUSTRIAL EXPERIENCE
Research Associate Quaid-i-Azam University Islamabad 2015 – 2016
Visiting Researcher University of Barcelona, Spain 2015 – 2015
Laboratory Scientist Shifa International Hospital Islamabad 2010 – 2014
MANAGEMENT EXPERIENCE
Patron GENIX Since – 2018
RESEARCH AREAS / INTERESTS
1. Cloning
2. Plant Biotechnology
3. Phytochemistry
4. DNA Barcoding
RESEARCH SUPERVISION
1. MS Determination of Active Constituents of Artemisia annua Against Viral Main Protease Mpro/CLpro to Treat SARS-CoV-2
2. MS Immunoregulatory and anti-inflammatory effects of bioactive compounds of garlic against Covid-19.
3. MS Identification of Active Constituents of Artemisia carvifolia against Breast Cancer
4. MS Identification of Anti-Viral Metabolites of Nigella sativa
5. MS Determination of potential inhibitors of SARS-COVID-19 present in Senna alexandrina
6. MS Determination of Potential Antioxidants of Artemisia annua by Computational Approaches
7. MS Identification of Anti-inflammatory Metabolites from Trigonella Foenum Graecum
8. MS Design, development and evaluation of antiseptic wound healing herbal pad
9. MS Prevalence of Hepatitis B and C in General Population and Transgender Population of Rawalpindi.
10. MS Pharmacological evaluation of Zinc oxide nanoparticles synthesized by using leaf extract of Bryophyllum pinnatum.
11. MS Synthesis and Evaluation of ZnO Nanoparticles of Trigonella foenum for their Biological Activities
12. MS Chromium Reduction and Plant Growth Promotion by Staphylococcus arlettae in Wheat
13. MS Greensynthesis,Characterizationand Therapeuticevaluation of zincoxide Nanoparticles using extractof Nigellasativa
14. MS Therapeutic evaluation of silver nanoparticles synthesized using Bryophyllum pinnatum plant extract
15. MS Biological Evaluation of Seeds of Trigonella Foenum (Methi) Plant and their Siver Nanoparticles
16. MS Biological evaluation of Silver Nanoparticles of Mentha Asiatica
17. MS Chemical Synthesis of Diversified Silver Nanoparticles along with Characterization and Biological Evaluation
18. MS Risk Factors Associated with Alteration of Hematological and Biochemical Parameters in G6PD Deficiency
19. MS Green Synthesis and Characterization of Silver Nanoparticles Using Leaf Extract of Artemisia Carvifolia and their Anti-Bacterial, Anti-Fungal, Anti-Oxidant, Cytotoxic Activities.
20. MS Optimization of Conditions for Micropropogation of Spinach (Spinacia oleracea).

SR.JOURNAL PUBLICATIONSYEAR
1H. Noor, A. Ayub, E. Dilshad, T. Afsar, S. Razak, F. M. Husain, and J. H. Trembley, “Assessment of bryophyllum pinnatum mediated ag and zno nanoparticles as efficient antimicrobial and cytotoxic agent,” Scientific Reports, vol. 14, no. 1, p. 22200, 2024.2024
2R. Tabassum and E. Dilshad, “A comparative anticancer analysis of iron oxide nanoparticles of hippophae rhamnoides and cichorium intybus found in the karakoram range of gilgit baltistan against liver cancer targeting the rhoa gene,” Drug Development and Industrial Pharmacy, pp. 1–10, 2024.2024
3I. Bashir and E. Dilshad, “A comparative study of mentha longifolia var. asiatica and zygophyllum arabicum zno nanoparticles against breast cancer targeting rab22a gene,” Plos One, vol. 19, no. 8, p. e0308982, 2024.2024
4H. Ismail, Z. Mubashar, H. Khan, Z. Naveed, E. Dilshad, M. Z. Bhatti, S. Anwaar, S. Saleem, S. Mehmood, A. Rahman et al., “Effects of a high trans fatty acid diet on kidney-, liver-, and heart-associated diseases in a rabbit model,” Metabolites, vol. 14, no. 8, p. 442, 2024.2024
5I. Ali, S. Aziz, M. Zahra, Y. Mu, E. Dilshad, M. Ali, and X. Wang, “Separation of non-alkaloid toxin lignans and new flavonoid from himalayan mayapple (podophyllum hexandrum royle) by high-speed counter-current chromatography and their anti-inflammatory activity evaluation,” Pakistan Journal of Analytical & Environmental Chemistry, vol. 25, no. 1, pp. 81–89, 2024.2024
6E. Irfan, E. Dilshad, F. Ahmad, F. N. Almajhdi, T. Hussain, G. Abdi, and Y. Waheed, “Phytoconstituents of artemisia annua as potential inhibitors of sars cov2 main protease: an in silico study,” BMC Infectious Diseases, vol. 24, no. 1, p. 495, 2024.2024
7I. Bashir, M. A. Khan, E. Dilshad, B. Siyo, E. Hussain, and I. Ali, “Antioxidant and anticancer silver nanoparticles of mentha asiatica aerial part extract: A novel study,” Inorganic and Nano-Metal Chemistry, vol. 54, no. 2, pp. 103–109, 2024.2024
8S. Javid and E. Dilshad, “Artemisia carvifolia buch silver nanoparticles downregulate the rap2a gene in liver cancer,” Scientific Reports, vol. 13, no. 1, p. 21553, 2023.2023
9H. Ismail, D. Khalid, D. Waseem, M. U. Ijaz, E. Dilshad, I.-u. Haq, M. Z. Bhatti, S. Anwaar, M. Ahmed, and S. Saleem, “Bioassays guided isolation of berberine from berberis lycium and its neuroprotective role in aluminium chloride induced rat model of alzheimer’s disease combined with insilico molecular docking,” Plos One, vol. 18, no. 11, p. e0286349, 2023.2023
10Z. Khurshid, N. M. Ashraf, and E. Dilshad, “Identification of potential antioxidant compounds of artemisia annua l. using computational approaches,” Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, vol. 66, no. 3, pp. 266–280, 2023.2023
11H. M. Khan, B. Bibi, E. Dilshad, and R. Rani, “Identification of anticancer potential of phytoconstituents of cuminum cyminum effective against hepatocellular carcinoma using computational approaches,” Life and Science, vol. 4, no. 3, pp. 14–14, 2023.2023
12U. Ali and E. Dilshad, “Comparison of nigella sativa seeds extract and respective zno nps for antimicrobial, antioxidant and cytotoxic potential,” Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences, vol. 66, no. 1, pp. 63–73, 2023.2023
13A. N. Khan and E. Dilshad, “Enhanced antioxidant and anticancer potential of artemisia carvifolia buch transformed with rol a gene,” Metabolites, vol. 13, no. 3, p. 351, 2023.2023
14H. Ashraf, E. Dilshad, T. Afsar, A. Almajwal, H. Shafique, and S. Razak, “Molecular screening of bioactive compounds of garlic for therapeutic effects against covid-19,” Biomedicines, vol. 11, no. 2, p. 643, 2023.2023
15H. Ismail, D. Khalid, S. B. Ayub, M. U. Ijaz, S. Akram, M. Z. Bhatti, M. M. Taqi, E. Dilshad, S. Anwaar, G. E.-S. Batiha et al., “Effects of phoenix dactylifera against streptozotocin-aluminium chloride induced alzheimer’s rats and their in silico study,” BioMed Research International, vol. 2023, no. 1, p. 1725638, 2023.2023
16E. Dilshad, M. Idrees, B. Sajid, A. Munir, and S. Fazal, “Non-toxic flavonoids of artemisia annua can be used as anti-cancer compounds: A computational analysis,” Life and Science, vol. 3, no. 4, pp. 12–12, 2022.2022
17E. Dilshad, M. Maaz, N. M. Ashraf et al., “Identification of anti-inflammatory metabolites from trigonella foenum-greacum using computational approaches,” Current Trends in OMICS, vol. 2, no. 1, pp. 55–88, 2022.2022
18E. Dilshad, F. Mehmood, R. Tariq, A. Munir, and S. Fazal, “Chemical constituents of artemisia annua are potent inhibitors of alpha-amylase in type ii diabetes,” Life and Science, vol. 3, no. 1, pp. 10–10, 2022.2022
19S. Safi, Y. Badshah, M. Shabbir, K. Zahra, K. Khan, E. Dilshad, T. Afsar, A. Almajwal, N. W. Alruwaili, D. Al-Disi et al., “Predicting 3d structure, cross talks, and prognostic significance of klf9 in cervical cancer,” Frontiers in Oncology, vol. 11, p. 797007, 2022.2022
20E. Dilshad, A. Asif, H. Arooj, S. H. Khan, and S. M. Bakhtiar, “Impact of BAP on in vitro regeneration of potato (solanum tuberosum l.),” Current Trends in OMICS, vol. 1, no. 2, pp. 67–79, 2021.2021
21S. M. Bakhtiar, S. E. Bokhari, I. Riasat, and E. Dilshad, “Elucidating the genetic factors contributing towards susceptibility and severity of covid 19,” Current Chinese Science, vol. 1, no. 6, pp. 595–607, 2021.2021
22E. Dilshad, Z. Nooruddin, S. Shaukat, A. Munir, S. M. Bakhtiar, and H. Ismail, “Identification of stress-induced mirnas and their targets in solanum lycopersicum,” Current Chinese Science, vol. 1, no. 4, pp. 397–405, 2021.2021
23I. Ali, G. H. Rizwani, U. Zafar, A. A. K. Khalil, Z. Farooq, E. Dilshad, A. Baseer, Z. Khan, M. Romman, Saqibullah and Z ul Haq “Antimicrobial activities of dalbergia sissoo dc. and caralluma tuberculata,” Bioscience Research, vol. 18, no. 2, pp. 1802–1809, 2021.2021
24E. Dilshad, “Effect of phoenix dactylifera extracts on anti-inflammatory, anticoagulant, analgesic and antidepressant activities,” Wulfenia, vol. 28, no. 2, pp. 107–139, 2021.2021
25A. U. Khayam, H. Patel, N. A. Faiola, A. E. Figueroa Milla, E. Dilshad, B. Mirza, Y. Huang, and M. S. Sheikh, “Quinovic acid purified from medicinal plant fagonia indica mediates anticancer effects via death receptor 5,” Molecular and Cellular Biochemistry, vol. 474, pp. 159–169, 2020.2020
26B. H. Kiani, W. K. Kayani, A. U. Khayam, E. Dilshad, H. Ismail, and B. Mirza, “Artemisinin and its derivatives: A promising cancer therapy,” Molecular Biology Reports, vol. 47, pp. 6321–6336, 2020.2020
27S. Latif, H. Ismail, M. R. Khan, A. A. Rahim, R. Mehboob, E. Dilshad, M. Sajid, S. I. Haider, S. Anwaar, and M. N. Majeed, “Pharmacological evaluation of acacia modesta bark for antipyretic, anti-inflammatory, analgesic, antidepressant and anticoagulant activities in sprague dawley rats.” Pakistan Journal of Pharmaceutical Sciences, vol. 33, no. 3, pp. 1015–1024, 2020.2020
28E. Dilshad, H. Ismail, M. A. Khan, R. M. Cusido, and B. Mirza, “Metabolite profiling of artemisia carvifolia buch transgenic plants and estimation of their anticancer and antidiabetic potential,” Biocatalysis and Agricultural Biotechnology, vol. 24, p. 101539, 2020.2020
29H. Mehfooz, A. Saeed, M. Faisal, F. A. Larik, U. Muqadar, S. Khatoon, P. A. Channar, H. Ismail, S. Bilquees, S. Rashid, E. Dilshad et al., “Facile one-pot synthesis, butyrylcholinesterase and α-glucosidase inhibitory activities, structure–activity relationship, molecular docking and dna–drug binding analysis of meldrum’s acid derivatives,” Research on Chemical Intermediates, vol. 46, pp. 2437–2456, 2020.2020
30I. Younus, H. Ismail, C. B. Rizvi, E. Dilshad, K. Saba, B. Mirza, and M. Tahir, “Antioxidant, analgesic and anti-inflammatory activities of in vitro and field-grown iceberg lettuce extracts,” J. Pharm. Pharmacogn. Res, vol. 7, pp. 343–355, 2019.2019
31E. Dilshad, S. S. Tazeem, Z. Bashir, A. H. Iqbal, A. S. Khokhar, N. Zahra, M. A. Khan, H. Ismail, and M. Shabbir, “Silver nanoparticles of aloe vera gel as strong therapeutic candidates,” IJB, vol. 15, no. 1, pp. 360–73, 2019.2019
32A. Kazmi, M. A. Khan, H. Ali and E. Dilshad, “Biotechnological approaches for production of bioactive secondary metabolites in nigella sativa: an up-to-date review,” International Journal of Secondary Metabolite, vol. 6, no. 2, pp. 172–195, 2019.2019
33H. Ali, M. A. Khan, W. K. Kayani, E. Dilshad, R. Rani, and R. S. Khan, “Production of biomass and medicinal metabolites through adventitious roots in ajuga bracteosa under different spectral lights,” Journal of Photochemistry and Photobiology B: Biology, vol. 193, pp. 109–117, 2019.2019
34S. Zafar, E. Dilshad, H. Ismail, C. B. Rizvi, and B. Mirza, “Rol genes enhance content of artemisinin and other secondary metabolites in shennong hybrid of artemisia annua,” Chinese Herbal Medicines, vol. 11, no. 2, pp. 209–215, 2019.2019
35S. Rehman, K. Keefover-Ring, I. u. Haq, E. Dilshad, M. I. Khan, N. Akhtar, and B. Mirza, “Drier climatic conditions increase withanolide content of withania coagulans enhancing its inhibitory potential against human prostate cancer cells,” Applied biochemistry and biotechnology, vol. 188, pp. 460–480, 2019.2019
36A. Munir, S. Hussain, and E. Dilshad, “Silver nanoparticles conjugated with neurotrophin 3 upregulate myelin gene transcription pathway,” Journal of Theoretical Biology, vol. 459, pp. 111–118, 2018.2018
37F. A. Larik, A. Saeed, M. Faisal, P. A. Channar, S. S. Azam, H. Ismail, E. Dilshad, and B. Mirza, “Synthesis, molecular docking and comparative efficacy of various alkyl/aryl thioureas as antibacterial, antifungal and -amylase inhibitors,” Computational Biology and Chemistry, vol. 77, pp. 193–198, 2018.2018
38W. K. Kayani, B. H. Kiani, E. Dilshad, and B. Mirza, “Biotechnological approaches for artemisinin production in artemisia,” World Journal of Microbiology and Biotechnology, vol. 34, pp. 1–14, 2018.2018
39H. Ismail, A. Rasheed, I.-u. Haq, L. Jafri, N. Ullah, E. Dilshad, M. Sajid, and B. Mirza, “Five indigenous plants of pakistan with antinociceptive, anti-inflammatory, antidepressant, and anticoagulant properties in sprague dawley rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, no. 1, p. 7849501, 2017.2017
40A. Saeed, P. A. Channar, F. A. Larik, F. Jabeen, U. Muqadar, S. Saeed, U. Fl¨orke, H. Ismail, E. Dilshad, and B. Mirza, “Design, synthesis, molecular docking studies of organotin-drug derivatives as multi-target agents against antibacterial, antifungal, -amylase, -glucosidase and butyrylcholinesterase,” Inorganica Chimica Acta, vol. 464, pp. 204–213, 2017.2017
41H. Ismail, E. Dilshad, M. T. Waheed, and B. Mirza, “Transformation of lettuce with rol abc genes: extracts show enhanced antioxidant, analgesic, anti-inflammatory, antidepressant, and anticoagulant activities in rats,” Applied Biochemistry and Biotechnology, vol. 181, pp. 1179–1198, 2017.2017
42F. A. Larik, A. Saeed, P. A. Channar, H. Ismail, E. Dilshad, and B. Mirza, “New 1-octanoyl-3-aryl thiourea derivatives: Solvent-free synthesis, characterization and multi-target biological activities,” Bangladesh Journal of Pharmacology, vol. 11, no. 4, pp. 894–902, 2016.2016
43W. K. Kayani, E. Dilshad, T. Ahmed, H. Ismail, and B. Mirza, “Evaluation of ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities,” BMC Complementary and Alternative Medicine, vol. 16, pp. 1–13, 2016.2016
44H. Ismail, E. Dilshad, M. T. Waheed, M. Sajid, W. K. Kayani, and B. Mirza, “Transformation of lactuca sativa l. with rol C gene results in increased antioxidant potential and enhanced analgesic, anti-inflammatory and antidepressant activities in vivo,” 3 Biotech, vol. 6, pp. 1–11, 2016.2016
45E. Dilshad, S. Zafar, H. Ismail, M. T. Waheed, R. M. Cusido, J. Palazon, and B. Mirza, “Effect of rol genes on polyphenols biosynthesis in artemisia annua and their effect on antioxidant and cytotoxic potential of the plant,” Applied Biochemistry and Biotechnology, vol. 179, pp. 1456–1468, 2016.2016
46E. Dilshad, H. Ismail, I.-u. Haq, R. M. Cusido, J. Palazon, K. Ramirez-Estrada, and B. Mirza, “Rol genes enhance the biosynthesis of antioxidants in artemisia carvifolia buch,” BMC Plant Biology, vol. 16, pp. 1–9, 2016.2016
47E. Dilshad, R. M. Cusido, J. Palazon, K. R. Estrada, M. Bonfill, and B. Mirza, “Enhanced artemisinin yield by expression of rol genes in artemisia annua,” Malaria Journal, vol. 14, pp. 1–10, 2015.2015
48E. Dilshad, R. M. Cusido, K. R. Estrada, M. Bonfill, and B. Mirza, “Genetic transformation of artemisia carvifolia buch with rol genes enhances artemisinin accumulation,” PLoS One, vol. 10, no. 10, p. e0140266, 2015.2015
49E. Dilshad, B. Mirza, M. Shabbir, Z. Haq, and Z. Akhter, “Biological evaluation of aza-heterocyclic derivatives and their intermediates,” World J. Pharm. Res., vol. 3, pp. 2111–2126, 2014.2014
50G. Murtaza, M. K. Rauf, A. Badshah, M. Ebihara, M. Said, M. Gielen, D. de Vos, E. Dilshad, and B. Mirza, “Synthesis, structural characterization and in vitro biological screening of some homoleptic copper (ii) complexes with substituted guanidines,” European Journal of Medicinal Chemistry, vol. 48, pp. 26–35, 2012.2012

SR.CONFERENCE PUBLICATIONSYEAR
1I. Bashir, E. Dilshad, “Analysis of Zygophyllum arabicum compounds against novel drug target of breast cancer,” C-BICS 2024.2024
2R. Tabassum, E. Dilshad, “Screening of Polyphenols of Hippophae rhamnoides and Cichorium intybus as inhibitors of RhoA protein against liver cancer,” C-BICS 2024.2024
3A. N. Khan, E. Dilshad, B. Mirza, “Agrobacterium tumefaciens Mediated Genetic Transformation of Lycopersicon esculentum Mill. For Enhancement of Abiotic Stress Tolerance,” C-BICS 2020 CUST Islamabad.2020
4S. Sojla, Z. Bashir, E. Dilshad, “Green Synthesis and Characterization of Silver Nanoparticles Using Alo vera Plant Gel and Their Biological Evaluation,” 1st National Conference on Medicinal Plant Research, Karakoram International University Gilgit Baltistan, 29-31 Aug 2018.2018
5E. Dilshad, “Genetic transformation of artemisia carvifolia buch with rol genes for enhancement of secondary metabolites,” Ph.D. dissertation, Quaid-i-Azam University Islamabad, Pakistan, 2016.2016
6E. Dilshad, “Genetic transformation of Lycopersicon esculentum Mill. using an abiotic stress tolerance gene,” 4th International Conference on Biological and Computer Science. December 2016.2016

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