Dr. Erum Dilshad

Dr. Erum Dilshad (PhD QAU, Islamabad)

ASSISTANT PROFESSOR
PROFILE SUMMARY

My research is focused on production of transgenics of both medicinal and edible crops for enhancement of secondary metabolites, tolerance against biotic and abiotic stress along with their phytochemical analysis. It also involves establishing plant tissue culture, biological evaluation of synthetic and natural compounds and cancer cell line studies.

QUALIFICATION
Ph.D Biochemistry/Plant Biotechnology Quaid-i-Azam University Islamabad 2016
M.phil Biochemistry/Molecular Biology Quaid-i-Azam University Islamabad 2010
M.Sc Biochemistry Quaid-i-Azam University Islamabad 2008
TEACHING EXPERIENCE
Assistant Professor Biosciences Capital University of Science and Technology (CUST), Islamabad Since 2016
Visiting Faculty (Biotechnology) 2016 – 2017 Allama Iqbal Open University, Islamabad 2016 – 2017
Visiting faculty (Biochemistry) CMT, PIMS, Islamabad 2009 – 2010
INDUSTRIAL EXPERIENCE
Research Associate Quaid-i-Azam University Islamabad 2015 – 2016
Visiting Researcher University of Barcelona, Spain 2015 – 2015
Laboratory Scientist Shifa International Hospital Islamabad 2010 – 2014
MANAGEMENT EXPERIENCE
Member CUST News Letter Committee
Convener Curriculum Review Committee (BS Biotechnology)
Member Board of Studies (BS Biotechnology)
Patron GENIX Since – 2018
Member Discipline Committee Since – 2018
Coordinator FYP 2017 – 2018
Coordinator MS Thesis Since – 2017
Coordinator Girls’ Sports activities Since – 2018
Member Departmental Program Team for BS Biosciences, Biotechnology, Microbiology and Bioinformatics Since – 2017
HONORS & AWARDS
1. Productive Scientist of Pakistan (2017) by PCST
2. Productive Scientist of Pakistan (2016) by PCST
3. HEC Interim placement of fresh PhDs (2016-2017)
4. HEC Talent Farming Scholarship during B.Sc
5. HEC Talent Farming Scholarship during M.Sc
6. Merit Based Scholarship from Quaid-i-Azam University Islamabad During M.Phil
7. HEC Indigenous Fellowship during Ph.D
8. HEC International Research Support Initiative Programe Fellowship during Ph.D
RESEARCH AREAS / INTERESTS

1. Cloning;
2. Plant Biotechnology;
3. Phytochemistry;
4. DNA Barcoding;
5. Drug Discovery;
6. Bioassays;
7. Cancer cell line studies;
8. Nanobiotechnology;

RESEARCH SUPERVISION
1. MS Determination of Active Constituents of Artemisia annua Against Viral Main Protease Mpro/CLpro to Treat SARS-CoV-2
2. MS Immunoregulatory and anti-inflammatory effects of bioactive compounds of garlic against Covid-19.
3. MS Identification of Active Constituents of Artemisia carvifolia against Breast Cancer
4. MS Identification of Anti-Viral Metabolites of Nigella sativa
5. MS Determination of potential inhibitors of SARS-COVID-19 present in Senna alexandrina
6. MS Determination of Potential Antioxidants of Artemisia annua by Computational Approaches
7. MS Identification of Anti-inflammatory Metabolites from Trigonella Foenum Graecum
8. MS Design, development and evaluation of antiseptic wound healing herbal pad
9. MS Prevalence of Hepatitis B and C in General Population and Transgender Population of Rawalpindi.
10. MS Pharmacological evaluation of Zinc oxide nanoparticles synthesized by using leaf extract of Bryophyllum pinnatum.
11. MS Synthesis and Evaluation of ZnO Nanoparticles of Trigonella foenum for their Biological Activities
12. MS Chromium Reduction and Plant Growth Promotion by Staphylococcus arlettae in Wheat
13. MS Greensynthesis,Characterizationand Therapeuticevaluation of zincoxide Nanoparticles using extractof Nigellasativa
14. MS Therapeutic evaluation of silver nanoparticles synthesized using Bryophyllum pinnatum plant extract
15. MS Biological Evaluation of Seeds of Trigonella Foenum (Methi) Plant and their Siver Nanoparticles
16. MS Biological evaluation of Silver Nanoparticles of Mentha Asiatica
17. MS Chemical Synthesis of Diversified Silver Nanoparticles along with Characterization and Biological Evaluation
18. MS Risk Factors Associated with Alteration of Hematological and Biochemical Parameters in G6PD Deficiency
19. MS Green Synthesis and Characterization of Silver Nanoparticles Using Leaf Extract of Artemisia Carvifolia and their Anti-Bacterial, Anti-Fungal, Anti-Oxidant, Cytotoxic Activities.
20. MS Optimization of Conditions for Micropropogation of Spinach (Spinacia oleracea).
21. BS Optimization of conditions for in vitro propagation of Solanum tuberosum.
22. BS Identification of stress-induced miRNA and their targets in Solanum tuberosum by computational approaches.
23. BS Characterization of silver nanoparticles of parsley (petroselinum Crispum)
24. BS Evaluation of silver nanoparticles of parsley (petroselinum Crispum) as antimicrobial agent.
25. BS Antifungal Analysis and Characterization of Green Synthesized Silver Nanoparticles.
26. BS Green Synthesized Silver Nanoparticles as Strong Antibacterial Agents.
27. BS Identification of Novel Inhibitors of Alpha Amylase as Antidiabetic Agents Using Computational Approaches.
28. BS In-silico Identification of stress-Induced miRNA and their targets in Solanum lycopersicum.
29. BS Identification of anti-cancer flavonoids from Artemisia annua using computational approaches.
BOOKS AUTHORED / AUTHORED
  1. Erum Dilshad, Huma Noor, Nabgha Nosheen, Syeda Rehab Gilani, Umar Ali, and Mubarak Ali Khan. “Influence of rol Genes for Enhanced Biosynthesis of Potent Natural Products.” Chemistry of Biologically Potent Natural Products and Synthetic Compounds (2021): 379-404.
  2. Erum Dilshad, Hasnain Waheed, Umar Ali, Arshia Amin, and Iftikhar Ahmed. “General Structure and Classification of Bioplastics and Biodegradable Plastics.” In Bioplastics for Sustainable Development, pp. 61-82. Springer, Singapore, 2021.
  3. Erum Dilshad, Hammad ismail, Hussnain Waheed, Muhammad Maaz (2020). Strategies for genetic transformation of Lactusa sativa In Book Lactusa cultivation and uses. Nova Pblishers.
  4. Hammad Ismail, Sara Latif, Fatima Ijaz, Erum Dilshad (2020). Lactusa sativa: An edible source of Medicinal plants In Book Lactusa cultivation and uses. Nova Publishers
  5. Amin, Arshia, Tehseen Zahra, Hafsa Raja, Mehroze Amin, Erum Dilshad, Muhammad Naveed, and Iftikhar Ahmed. “Major natural sinks for harboring microorganisms with altered antibiotic resistance versus major human contributing sources of antibiotic resistance: a detailed insight.” In Antibiotics and Antimicrobial Resistance Genes in the Environment, pp. 70-98. Elsevier, 2020.
  6. Erum Dilshad, Naqoosh Zahra, Zainab Nooruddin, Arshia Amin Butt, and Syeda Marriam Bakhtiar. (2019) “Single-Cell Editing: The CRISPR/Cas9 and Applications.” In Single-Cell Omics, pp. 397-415. Academic Press
  7. S M Bakhtiar, Butt HA, Zeb S, Quddusi DM, Gu l S, Dilshad E ( 2017). 3D Printing Technologies and Their Applications in Biomedical Sciences. Book Omics Technologies and Bioengineering. ISBN 978-0-1280-4659-3.
JOURNAL PUBLICATIONS
1. Erum Dilshad, Farkhanda Mehmood, Rida Tariq, Anum Munir, Sahar Fazal (2022). Chemical Constituents of Artemisia annua are Potent Inhibitors of Alpha-Amylase in Diabetes II. Life and Science. 3(1). 1-10.
2. Iqra Bashir, Mubarak Ali Khan, Erum Dilshad, Bara Siyo, Ejaz Hussain & Iftikhar Ali (2021) Antioxidant and anticancer silver nanoparticles of Mentha asiatica aerial part extract: a novel study, Inorganic and Nano-Metal Chemistry, DOI: 10.1080/24701556.2021.2021945 .
3. Sadia Safi, Yasmin Badshah, Maria Shabbir, Kainat Zahra, Erum Dilshad, Dara Al-disi, Dara Assad Aldisi, Mahmoud M. Abulmeaty, and Suhail Razak. “Predicting 3D structure, cross-talks and prognostic significance of KLF 9 in cervical cancer.” Frontiers in Oncology: 5382.
4. Hammad Ismail, Muhammad Umar Ijaz, Muhammad Zeeshan Bhatti, Hajira Liaquat, Neelam Nawaz, Iqra Zafar, Mohamed A. Nassan, Rania M. Waheed, Reem H. Badr, Sara Latif, Muhammad Suleman Malik, Erum Dilshad, Mohammad Tahir Waheed, Gaber El-Saber Batiha (2021). Effect of Phoenix dactylifera extracts on anti-inflammatory, anticoagulant, analgesic and antidepressant activities. Wulfenia. 28(2).
5. Zahoor ul Haq Ijaz Ali, Ghazala Hafeez Rizwani, Urooj Zafar, Atif Ali Khan Khalil, Zahid Farooq, Erum Dilshad, Abdul Baseer, Zahid Khan, and Muhammad Romman, Saqibullah (2021). Antimicrobial activities of Dalbergia sissoo DC. and Caralluma tuberculate. Bioscience Research. 18(2). 1802-1809.
6. Erum Dilshad, Zainab Nooruddin, Shadab Shaukat, Anum Munir, Syeda Marriam Bakhtiar and Hammad Ismail (2021). Identification of Stress-induced miRNA and their targets in Solanum lycopersicum. Current Chinese Science. DOI: 10.2174/2210298101666210617095627.
7. Syeda Marriam Bakhtiar, Syeda Eeman Zahra Bokhari, Iqra Riasat and Erum Dilshad (2021). Elucidating the Genetic Factors Contributing Towards Susceptibility and Severity of Covid 19. Current Chinese Science. DOI: 10.2174/2210298101666210914085627.
8. Khayam, Asma Umer, Harsh Patel, Nicholas A. Faiola, Andre E. Figueroa Milla, Erum Dilshad, Bushra Mirza, Ying Huang, and M. Saeed Sheikh. “Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5.” Molecular and Cellular Biochemistry (2020): 1-11.
9. Kiani, Bushra Hafeez, Waqas Khan Kayani, Asma Umer Khayam, Erum Dilshad, Hammad Ismail, and Bushra Mirza. “Artemisinin and its derivatives: a promising cancer therapy.” Molecular Biology Reports (2020): 1-16.
10. Latif, Sara, Hammad Ismail, Muhammad Rashid Khan, Amna Abdul Rahim, Ramsha Mehboob, Erum Dilshad, Moniba Sajid, Syed Ihtisham Haider, Sadaf Anwaar, and Muhammad Naveed Majeed. “Pharmacological evaluation of Acacia modesta bark for antipyretic, anti-inflammatory, analgesic, antidepressant and anticoagulant activities in Sprague Dawley rats.” Pakistan Journal of Pharmaceutical Sciences 33, no. 3 (2020).
11. Erum Dilshad, Hammad Ismail, Mubarak Ali Khan, Rosa Maria Cusido, and Bushra Mirza. “Metabolite profiling of Artemisia carvifolia Buch transgenic plants and estimation of their anticancer and antidiabetic potential.” Biocatalysis and Agricultural Biotechnology 24 (2020): 101539.
12. Mehfooz, Haroon, Aamer Saeed, Muhammad Faisal, Fayaz Ali Larik, Urooj Muqadar, Saira Khatoon, Pervaiz Ali Channar et al. “Facile one-pot synthesis, butyrylcholinesterase and α-glucosidase inhibitory activities, structure–activity relationship, molecular docking and DNA–drug binding analysis of Meldrum’s acid derivatives.” Research on Chemical Intermediates (2020): 1-20.
13. Iqra Younus, Hammad Ismail, Chahat Batool Rizvi, Erum Dilshad, Kiran Saba, Bushra Mirza, Mohammad Tahir Waheed. J Pharm Pharmacogn 7 (5) (2019): 343-355.
14. Erum Dilshad, Syeda Sojla Tazeem, Zainab Bashir, Ammar Hamza Iqbal, Adeel Saddique Khokhar, Naqoosh Zahra, Mubarak Ali Khan, Hammad Ismail, Maria Shabbir. “Silver nanoparticles of Aloe vera gel as strong therapeutic candidates.” Int. J. Biosci (2019). 15(1), 360-373.
15. Kazmi, Abeer, Mubarak Ali Khan, Huma Ali, Erum Dilshad. “Biotechnological approaches for production of bioactive secondary metabolites in Nigella sativa: an up-to-date review.” International Journal of Secondary Metabolite 6, no. 2 (2019): 172-195.
16. Ali, Huma, Mubarak Ali Khan, Waqas Khan Kayani, Erum Dilshad, Rehana Rani, and Raham Sher Khan. “Production of biomass and medicinal metabolites through adventitious roots in Ajuga bracteosa under different spectral lights.” Journal of Photochemistry and Photobiology B: Biology 193 (2019): 109-117.
17. Zafar, Sara, Erum Dilshad, Hammad Ismail, Chahat Batool Rizvi, and Bushra Mirza. “Rol genes enhance content of artemisinin and other secondary metabolites in Shennong hybrid of Artemisia annua.” Chinese Herbal Medicines (2019).
18. Rehman, Samiya, Ken Keefover-Ring, Ihsan ul Haq, Erum Dilshad, Mohammad Imran Khan, Nosheen Akhtar, and Bushra Mirza. “Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells.” Applied biochemistry and biotechnology (2018): 1-21.
19. Munir, Anum, Shahid Hussain, and Erum Dilshad. “Silver nanoparticles conjugated with Neurotrophin 3 upregulate myelin gene transcription pathway.” Journal of theoretical biology 459 (2018): 111-118.
20. Larik, Fayaz Ali, Aamer Saeed, Muahmmad Faisal, Pervaiz Ali Channar, Syed Sikandar Azam, Hammad Ismail, Erum Dilshad, and Bushra Mirza. “Synthesis, molecular docking and comparative efficacy of various alkyl/aryl thioureas as antibacterial, antifungal and α-amylase inhibitors.” Computational biology and chemistry 77 (2018): 193-198.
21. Waqas khan kiani, Bushra Hafeez Kiani, Erum Dilshad, Bushra Mirza, “Biotechnological approaches for artemisinin production in Artemisia”, World Journal of Microbiology and Biotechnology, No: 4, 2018
22. Hammad Ismail, Ammara Rasheed, Ihsan ul Haq, Laila Jafri, Nazif Ullah, Erum Dilshad, Moniba Sajid, Bushra Mirza, “Five indigenous plants of Pakistan with anti-nociceptive, antiinflammatory, anti-depressant and anti-coagulant properties in Sprague Dawley rats”, Evidence based complementary and alternative medicine, 2017
23. Aamer Saeed, Pervaiz Ali Channar, Fayaz Ali Larik, Farukh Jabeen, Urooj Muqadar, Shomaila Saeed, Ulrich Flörke, Hammad Ismail, Erum Dilshad, Bushra Mirza , “Design, Synthesis, Molecular docking studies of organotin-drug derivatives as multi-target agents against antibacterial, antifungal, a-amylase, a-glucosidase and buytyrlcholinesterase”, Inorganica Chimica Acta, Pages: 204-213, 2017
24. Ismail, Hammad, Erum Dilshad, Mohammad Tahir Waheed, and Bushra Mirza, “Transformation of Lettuce with rol ABC Genes: Extracts Show Enhanced Antioxidant, Analgesic, Anti-Inflammatory, Antidepressant, and Anticoagulant Activities in Rats”, Applied Biochemistry and Biotechnology (Springer), Pages: 1-20, 2017
25. Fayaz Ali Larik, Aamer Saeed, Pervaiz Ali Channar, Hammad Ismail, Erum Dilshad, Bushra Mirza, “New 1-octanoyl-3-aryl thiourea derivatives: Solvent-free synthesis, characterization and multi-target biological activities”, Bangladesh Journal of Pharmacology, Pages: 894-902, 2016
26. Kayani, Waqas Khan, Erum Dilshad, Tanveer Ahmed, Hammad Ismail, and Bushra Mirza, “Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities”, BMC Complementary and Alternative Medicine (Springer), No: 1, Pages: 375, 2016
27. Ismail, Hammad, Erum Dilshad, Mohammad Tahir Waheed, Moniba Sajid, Waqas Khan Kayani, and Bushra Mirza, “Transformation of Lactuca sativa L. with rol C gene results in increased antioxidant potential and enhanced analgesic, anti-inflammatory and antidepressant activities in vivo”, 3 Biotech (Springer), No: 2, Pages: 215, 2016
28. Erum Dilshad, Sara zafar, Hammad Ismail, Mohammad Tahir Waheed, Rosa Maria Cusido, Javier Palazon, Bushra Mirza, “Effect of Rol Genes on Polyphenols Biosynthesis in Artemisia annua and Their Effect on Antioxidant and Cytotoxic Potential of the Plant”, Appl Biochem Biotechnol, No: 8, Pages: 1456-1458, 2016
29. Erum Dilshad, Hammad Ismail, Ihsan-ul-Haq, Rosa Maria Cusido, Javier Palazon, Karla Ramirez Estrada, Bushra Mirza, “Rol genes enhance the biosynthesis of antioxidants in A. carvifolia Buch”, BMC Plant Biology, 2016
30. Erum Dilshad, Rosa Maria Cusido, Javier Palazon, Karla Ramirez Estrada, Mercedes Bonfill, Bushra Mirza, “Enhanced artemisinin yield by expression of rol genes in Artemisia annua”, Malaria Journal, Pages: 424, 2015
31. Erum Dilshad, Rosa Maria Cusido, Karla Ramirez Estrada, Mercedes Bonfill, Bushra Mirza , “Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation”, Plos One, No: 10, Pages: e0140266., 2015
32. Erum Dilshad, Bushra Mirza1, Muhammad Shabbir, Zia-ul- Haq, Zareen Akhter, “Biological Evaluation of Aza-Heterocyclic Derivatives and their Intermediates”, World J Pharmaceutical Sciences, No: 6, Pages: 2111-2126, 2014
33. Ghulam Murtaza, Muhammad Khawar Rauf, Amin Badshah, Masahiro Ebihara, Muhammad Said, Marcel Gielen, Dick de Vos, Erum Dilshad, Bushra Mirza , “Synthesis, structural characterization and in vitro biological screening of some homoleptic copper(II) complexes with substituted guanidines”, European J Chemistry, Pages: 26-35, 2012
CONFERENCE PUBLICATIONS
1. Amna Naheed Khan, Erum Dilshad, Bushra Mirza (2020). “Agrobacterium tumefaciens Mediated Genetic Transformation of Lycopersicon esculentum Mill. For Enhancement of Abiotic Stress Tolerance. C-BICS 2020 CUST Islamabad.
2. Syeda Sojla, Zainab Bashir, Erum Dilshad. “Green Synthesis and Characterization of Silver Nanoparticles Using Alo vera Plant Gel and Their Biological Evaluation”.1st National Conference on Medicinal Plant Research. Karakoram International University Gilgit Baltistan. 29-31 Aug 2018.
3 ISESCO WINS 2016 conference Quaid-i-Azam University Islamabad March 2016. Genetic transformation of Artemisia carvifolia Buch with rol genes for enhancement of secondary metabolites. Poster Presentation.
4. 4th International Conference on Biological and Computer Science. December 14, 2016. Genetic transformation of Lycopersicon esculentum Mill. using an abiotic stress tolerance gene. Poster presentation

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