Dr. Sahar Fazal

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Dr. Sahar Fazal

Professor/Dean Faculty of Health & Life Sciences

sahar@cust.edu.pk

+92-51-111-555-666

PROFILE SUMMARY

Dr. Sahar Fazal is a Professor at department of Bioinformatics and Biosciences. Since 2005, Dr. Sahar Fazal has been actively contributing to CUST. She earned her PhD in Molecular Entomology from South China Agriculture University, Guangzhou, China. Following that, she pursued her Post doc in Biochemistry and Molecular Genetics at the University of Sussex, England. For over a decade, she has been engaged in the field of education, and her teaching abilities are well-received by students. Dr. Sahar’s research focuses on Bioinformatics, Systems Biology, Entomology, Microbiology and Phylogenetics. She has established international connections with various universities globally. Her scientific findings have been published in well-regarded international journals and presented at diverse international forums. Additionally, she serves as a reviewer for several international journals and has authored multiple book chapters.

QUALIFICATION
PhD	Applied Entomology	South China Agriculture University, Guangzhou, People Republic of China	2004
MSc	Applied Entomology	University of Agriculture Faisalabad, Pakistan	1998

TEACHING EXPERIENCE
Professor	Capital University of Science and Technology, Islamabad	Since – 2021
Associate Professor	Mohammad Ali Jinnah University, Islamabad	2012 – 2020
Assistant Professor	Mohammad Ali Jinnah University, Islamabad	2005 – 2012

MANAGEMENT EXPERIENCE
Dean	Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad	Since – 2022
HoD	Department of Bioinformatics and Biosciences, Capital University of Science and Technology (CUST), Islamabad	2019 – 2022

RESEARCH AREAS / INTERESTS
1.	Phylogenetics
2.	Protein Interactions
3.	Modeling
4.	Pathways

RESEARCH SUPERVISION
1.	PhD	Molecular Identification and Phylogenetic studies of some Passerines of Pakistan based on Oxidase Subunit I.
2.	PhD	Genome wide mapping of chromatin states based on histone combinatorics for determination of epigenetic expression (2016).
3.	PhD	Construction Of Biological Association Network For Connected Components Analysis Using Graph Theory
4.	PhD	Elastic Network Modelling of Virus Protein Interactions.
5.	MS	Linkage Analysis and Subgroup Discovery of Maturity-onset Diabetes of the young Genes From Text Documents
6.	MS	Association Study and Computational Analysis of TGFB1& FGFR2 Polymorphism in correlation to Breast Cancer Susceptibility in Pakistani Women
7.	MS	Insilico Analysis of CRBN and GRIK2 Gene Implicated in Nonsyndromic Autosomal Recessive Mental Retardation (ARNSMR)
8.	MS	Structural Based Virtual Screening of Novel Inhibitors of Human Papillomavirus-16 E6 Protein and Optimization through Molecular Dynamic Simulation.
9.	MS	Impact of Normalization Techniques on Downstream Analysis of Differentialy Expressed Gene Data
10.	MS	Identification and Classification of Asthma Related Risk Factors and Symptoms By Using Computational Approach.
11.	MS	Computational assay for epitope Based peptide designing of ebola Virus
12.	MS	Computer Aided drug designing of hereditary angiodema by using data mining approach
13.	MS	Comparative Analysis of Insilico Classification Techniques to Classify SGLT2 Inhibitors (2015)
14.	MS	Computational assay for drug designing of Antiphospholipd Syndrome. (2016)
15.	MS	Mathematical Modeling of E6 Protein of Human Papiloma Virus
16.	MS	P53 Revival Using System Oriented Dosage Design Targeting MDM2. (2017)
17.	MS	Integrated Pathway Mapping of Renal Cell Carcinoma from Biological Resources (2013)

SR.	JOURNAL PUBLICATIONS	YEAR
1	S. Elahi and S. Fazal, “Gene expression profiling to predict prognostic biomarkers for relapse in multiple myeloma,” Advancements in Life Sciences, vol. 11, no. 2, pp. 329–337, 2024.	2024
2	A. Tariq and S. Fazal, “Exploring genomic patterns to identify drug-resistant Tb: A comprehensive study of age, gender, lineage, and outcome,” Advancements in Life Sciences, vol. 11, no. 2, pp. 354–361, 2024.	2024
3	S. W. Noor, S. Arshad, S. M. Abdullah, B. K. Kayani, and S. Fazal, “16s rRNA gene sequencing reveals bacterial diversity in khewra salt mine walls.” Access Microbiology, Vol. 6, no. 2, pp. 1-11, 2024.	2024
4	R. Farooq, S. Bibi, R. M. Malik, F. Siraj, and S. Fazal, “Isolation and characterization of human health-concerned bacteria from the musca domestica in urban environments of districts rawalpindi and chakwal, pakistan,” Life and Science, vol. 4, no. 3, pp. 242–252, 2023.	2023
5	F. Nazir, S. Fazal, F. I. Abbas, “Corvidae in pakistan are represented by two distinct clades revealed through maternally inherited gene region.” Pakistan Journal of Zoology, vol. 55, no. 4, pp. 1509-1516, 2023.	2023
6	A. Munir, S. Fazal, A. I. Bhatti, and B. Sajjad, “Pharmacokinetics pharmacodynamics modeling and evaluation of tumor response to bortezomib proteasome inhibitor in waldenstrom macroglobulinemia,” American Journal of Clinical Oncology, vol. 46, no. 4, pp. 150–160, 2023.	2023
7	N. Khan, S. Fazal, R. M. Malik, S. Azam, A. Kanwal, Z. K. Shinwari, A. K. Shinwari, and S. A. Jan, “In silico analysis of turmeric as anti-inflammatory agent against Ace2 receptor,” Pakistan Journal of Botany, vol. 55, no. 2, pp. 1-16, 2023.	2023
8	E. Dilshad, F. Mehmood, R. Tariq, A. Munir, and S. Fazal, “Chemical constituents of artemisia annua are potent inhibitors of alpha-amylase in type ii diabetes,” Life and Science, vol. 3, no. 1, pp. 3–12, 2022.	2022
9	E. Dilshad, M. Idrees, B. Sajid, A. Munir, and S. Fazal, “Non-toxic flavonoids of artemisia annua can be used as anti-cancer compounds: A computational analysis,” Life and Science, vol. 3, no. 4, pp. 151–162, 2022.	2022
10	A. Sajid, M. S. Saeed, R. M. Malik, S. Fazal, S. Malik, and M. A. Kamal, “Prediction of secondary and tertiary structure and docking of Rb1WT and Rb1R661W proteins,” Current Biotechnology, vol. 11, no. 1, pp. 71–85, 2022.	2022
11	N. Noureen, S. Fazal, M. A. Qadir, and M. T. Afzal, “HCVS: pinpointing chromatin states through hierarchical clustering and visualization scheme,” Current Bioinformatics, vol. 14, no. 2, pp. 148–156, 2019.	2019
12	A. Kanwal and S. Fazal, “Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis,” Gene, vol. 638, pp. 41–51, 2018.	2018
13	A. Munir, S. Azam, S. Aslam, A. Mehmood, G. M. Shah, S. Amjad, M. Younis, and S. Fazal, “Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions,” Informatics in Medicine Unlocked, vol. 12, pp. 1–5, 2018.	2018
14	A. Munir, S. Azam, S. Fazal, and A. Bhatti, “Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs,” Journal of Theoretical Biology, vol. 451, pp. 1–9, 2018.	2018
15	M. R. Azam, S. Fazal, M. Ullah, and A. I. Bhatti, “System-based strategies for p53 recovery,” IET Systems Biology, vol. 12, no. 3, pp. 101–107, 2018.	2018
16	S. Azam, A. Munir, M. Saad Khan, S. Fazal, A. Mehmood, S. Ali, and S. Hussain, “In-silico identification of novel resistant genes for fungal pathogen fusarium oxysporum f. sp. cubense race 4: Causative agent of banana vascular wilt disease,” Journal of Plant Biochemistry & Physiology, vol. 5, no. 01, p. 100175, 2017.	2017
17	M. Haseeb, S. Azam, A. Bhatti, R. Azam, M. Ullah, and S. Fazal, “On p53 revival using system oriented drug dosage design,” Journal of Theoretical Biology, vol. 415, pp. 53–57, 2017.	2017
18	F. Khattak, M. Haseeb, S. Fazal, A. Bhatti, and M. Ullah, “Mathematical modeling of E6-p53 interactions in cervical cancer,” Asian Pacific Journal of Cancer Prevention: APJCP, vol. 18, no. 4, p. 1057, 2017.	2017
19	N. Noureen, H. M. Zohaib, M. A. Qadir, and S. Fazal, “Chrombisim: Interactive chromatin biclustering using a simple approach,” Genomics, vol. 109, no. 5-6, pp. 353–361, 2017.	2017
20	R. Tabassum, M. Haseeb, and S. Fazal, “Structure prediction of outer membrane protease protein of salmonella typhimurium using computational techniques.” International Journal Bioautomation, vol. 20, no. 1, pp. 5-18, 2016.	2016
21	A. Munir, S. Azam, M. Manzoor, A. Mehmood, G. M. Shah and S. Fazal, ”In-silico epitope based vaccine an excellent solution against Marburg virus," Journal of Innovation in Pharmaceuticals and Biological Sciences, vol. 03, pp. 61-66, 2016.	2016
22	A. Munir, S. Azam, S. Fazal, Z. Khan, and A. Mehmood, “In silico repositioning of alendronate and cytarabine drugs to cure mutations of FPPS, HAP, PTPRS, PTPRE, PTN4, GGPPS gene and mutant DNA, DPOLB, TOP2A, DPOLA, DNMT, RNA, TYSY, RIR genes," International Journal BIOautomation, vol. 20, no. 3, pp. 317-328, 2016.	2016
23	M. Nisar, N. Noureen, S. Fazal, and M. A. Qadir, “MCaVoh: A toolkit for mining, classification and visualization of human microbiota," Journal of Microbiological Methods, vol. 117, pp. 28–35, 2015.	2015
24	M. T. Khan, S. Fazal, A. U. Rehman, and T. Zeb, “Interleukin 10 (IL-10) promoter-1082 A > G polymorphism and risk of cancer: Meta-analysis," Advancements in Life Sciences, vol. 2, no. 2, pp. 67–73, 2015.	2015
25	A. Munir, S. Azam, S. Fazal, ”Repositioning of Methotrexate to Cure Mutations of DYR, TYMS and PURA Gene, Bleomycin in the Treatment of Mutant DNA, TOPa, POLa, and RIR Genes," Merit Research Journal of Medicine and Medical Sciences, vol. 3, no. 7, pp. 249-255, 2015.	2015
26	F. Khattak, M. Haseeb, and S. Fazal, “Molecular homology modeling & docking studies to predict the 3D structure and drug determination for HBV core of hepatitis B," Journal of Chemical and Pharmaceutical Research, vol. 7, no. 5, pp. 1136–1146, 2015.	2015
27	M. S. Khan and S. Fazal, “Advanced modelling and functional characterization of B2 bradykinin receptor," International Journal Bioautomation, vol. 19, no. 2, 2015.	2015
28	N. Noureen, M. Touseef, S. Fazal, and M. A. Qadir, “Chromclust: A semi-supervised chromatin clustering toolkit for mining histone modifications interplay," Genomics, vol. 106, no. 6, pp. 355–359, 2015.	2015
29	M. Haseeb, S. Vaqar, S. Fazal, and A. Khalil, “Ligand based pharmacophore development for colorectal cancer drugs," The Professional Medical Journal, vol. 21, no. 05, pp. 856–863, 2014.	2014
30	U. Shaukat, M. Toor, B. Ahmad, S. Fazal, and N. Mehmood, “Genetic and computational analysis of TGFB1 & FGFR2 polymorphism in correlation to breast cancer susceptibility in Pakistani women," Journal of Cancer Science & Therapy, vol. 6, no. 11, pp. 433–439, 2014.	2014
31	S. Zeb, S. Rehman, M. S. Khan, S. Fazal, and S. Hussain, “Journal of Rashid Latif Medical College review," Journal of Rashid Latif Medical College, vol. 3, vol. 1, pp. 49–53, 2014.	2014
32	M. T. Khan and S. Fazal, “CYP3A5 polymorphism and the risk of cancer: A meta-analysis," European Scientific Journal, vol. 10, no. 30, pp. 389–398, 2014.	2014
33	S. Bilal, S. B. Ali, S. Fazal, and A. Mir, “Generation of a 3D model for human cereblon using comparative modelling," Journal of Bioinformatics and Sequence Analysis, vol. 5, no. 1, pp. 10–15, 2013.	2013
34	M. H. Khan, S. Fazal, R. Bano, and H. Rashid, “A miracle if restored, p53," African Journal of Biotechnology, vol. 12, no. 24, pp. 3745–3751, 2013.	2013
35	A. Kanwal, S. Fazal, S. Asghar, and M. Naeem, “MODY genes: Linkage analysis and subgroup discovery from text documents," The Professional Medical Journal, vol. 20, no. 04, pp. 623–633, 2013.	2013
36	A. Kanwal, S. Fazal, S. Asghar, and M. Naeem, “Subgroup discovery of the MODY genes: From text documents," The Professional Medical Journal, vol. 20, no. 05, pp. 644–652, 2013.	2013
37	S. A. Shad, A. H. Sayyed, S. Fazal, M. A. Saleem, S. M. Zaka, and M. Ali, “Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in spodoptera litura fab. (lepidoptera: Noctuidae)," Journal of Pest Science, vol. 85, pp. 153–162, 2012.	2012
38	K. Attiya and S. Fazal, “Maturity-onset diabetes of the young (MODY) genes: Literature review," Clinical Practice, vol. 1, no. 1, pp. 4–11, 2012.	2012
39	A. Kanwal, S. Fazal, M. Ismail, and N. Naureen, “A narrative insight to maturity-onset diabetes of the young," Clinical Review & Opinions, vol. 3, no. 1, pp. 6–13, 2011.	2011
40	K. Attiya, S. Fazal, M. Ismail, M. Qaisar, and J. Amara, “Linkage analysis of first six MODY genes to known loci and screening of three most prevalent MODY genes in Pakistani population," International Journal of Genetics, vol. 3, no. 1, pp. 35–46, 2011.	2011
41	R. Bano, S. Fazal, M. H. Khan, and H. Rashid, “miRNAs: Small but deadly," African Journal of Biotechnology, vol. 10, no. 47, pp. 9542–9548, 2011.	2011
42	Y. Bukhari, S. Fazal, and H. Rashid, “Bioinformatics techniques for designing antiviral agents against influenza," vol. 1, no. 07, pp. 168-177, 2011.	2011
43	S. Khan, S. Fazal, and A. Jilani, “Predoms: A computational toolkit developed to perform prediction of domains from sequence," World Applied Sciences Journal, vol. 8, pp. 44–46, 2010.	2010
44	Z. Huang, S. Fazal, S. Ren, and S. Ali, “Effect of isaria fumosoroseus on eretmocerus sp. nr. furuhashii (hymenoptera: Aphelinidae), a parasitoid of bemisia tabaci (hemiptera: Aleyrodidae)," Pakistan Journal of Zoology, vol. 42, no. 2, pp. 121-127, 2010.	2010
45	S. Fazal and R. S. Xiang, “Interaction of serangium japonicum (coleoptera: Coccinellidae), an obligate predator of whitefly with immature stages of eretmocerus sp. (hymenoptera: Aphelinidae) within whitefly host (homoptera: Aleyrodidae)," Asian Journal of Plant Science, vol. 3, pp. 243-246, 2004.	2004
46	N. S. Mandour, S. Ren, B. Qiu, and S. Fazal, “Effects of extraction from nymphs, exuviae and adults of bemisia tabaci B biotype on the behavior of encarsia bimaculata heraty et polaszek (hymenoptera: Aphelinidae)," Acta Entomologica Sinica, vol. 46, no. 6, pp. 745–748, 2003.	2003

SR.	CONFERENCE PUBLICATIONS	YEAR
1	M. N. Sharif, A. I. Bhatti, and S. Fazal, “Observer design and analysis of wnt-cell cycle joint pathway,” in 2017 11th Asian Control Conference (ASCC). IEEE, 2017, pp. 1470–1475.	2017
2	A. I. Bhatti, M. Haseeb, S. Azam, S. Fazal, and M. Ullah, “State feedback based intervention design in wnt and cell cycle network,” in 2017 American Control Conference (ACC). IEEE, 2017, pp. 4242–4247.	2017
3	S. E. Aziz, S. Fazal, S Hussain and H. Rashid, “Detection of relationship between breast cancer and ovarian cancer through network analysis,” In 2014 2nd conference on emerging trends in Bioinformatics: M.A.J.U Islamabad, Pages: 19, MAJU Islamabad.	2014
4	S. Sayyab, A. Nadeem, and S. Fazal, “Bvirusgs: Dna analysis toolkit for begomovirus genome analysis,” in 2009 IEEE 13th International Multitopic Conference. IEEE, 2009, pp. 1–5.	2009
5	N. Noureen, N. Kulsoom, A. de la Fuente, S. Fazal, and S. I. Malik, “Functional and promoter enrichment based analysis of biclustering algorithms using gene expression data of yeast,” in 2009 IEEE 13th International Multitopic Conference. IEEE, 2009, pp. 1–6.	2009
6	A. Nasreen, S. Fareed, M. G. Cheema, S. Fazal, and M. A. Saleem, “Effect of different insecticides on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae),” in 25th International Zoological Conference, 2005.	2005
7	A. Nasreen, G. M. Cheema, S. Fazal, and K. Hanife, “Effect of different storage temperatures on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference, 2005.	2005
8	S. Fazal, S. X. Ren, “Application of Eretmocerus sp., Serangium japonicum combined with buprofezin against B biotype Bemisia tabaci”. International Plant Protection Congress. Beijing, China, 11-16 May, 2004.	2004

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Dr. Sahar Fazal

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