Dr. Sahar Fazal

PROFILE SUMMARY

I’ve completed my PhD degree in Entomology from South China Agriculture University, Guangzhou, China. I’ve done my Post Doc in Molecular genetics and Biochemistry. My research interests are in Bioinformatics (Phylogenetics, Protein Interactions, Modeling and Simulation, Pathways), Resistance Management, Medical Entomology, Microbiology and Genetics.

QUALIFICATION
Post Doc	Biochemistry and Molecular Genetics	University of Sussex, Brighton, UK	2008
PhD	Applied Entomology	South China Agriculture University, Guangzhou, People Republic of China	2004
MSc	Applied Entomology	University of Agriculture Faisalabad, Pakistan	1998
BSc	Entomology

TEACHING EXPERIENCE
Professor	Capital University of Science and Technology, Islamabad	Since – 2021
Associate Professor	Mohammad Ali Jinnah University, Islamabad	2012 – 2020
Assistant Professor	Mohammad Ali Jinnah University, Islamabad	2005 – 2012

HONORS & AWARDS
1.	Bronze Medalist in B.Sc (Hons.), Bahuddin Zakariya University, Multan
2.	Talent scholarship in M. Sc (Hons.) for best performance from University of Agriculture, Faisalabad.
3.	Cultural exchange scholarship for PhD in China
4.	HEC Post doc fellowship in Biochemistry and Molecular Genetics
5.	3rd prize for poster presentation in International Society of Invertebrate Pathology (SIP) and COST organized at Warwick, UK

RESEARCH AREAS / INTERESTS

1. Phylogenetics
2. Protein Interactions
3. Modeling
4. Pathways
5. Resistance Management
6. Molecular Entomology
7. Microbiology and Genetics

RESEARCH SUPERVISION
1.	PhD	Genome wide mapping of chromatin states based on histone combinatorics for determination of epigenetic expression (2016).
2.	PhD	Ankylosing spondylitis Modeling And Expression Analysis by using Statistical Methods. (In Progress)
3.	PhD	Risk Factor Analysis of Gynecological Cancers in Pakistani Population.(In Progress)
4.	PhD	Phylogenetic Analysis of Pakistanis Sparrows using DNA Barcoding
5.	PhD	Elastic Network Modelling of Virus Protein Interactions.
6.	MS	Linkage Analysis and Subgroup Discovery of Maturity-onset Diabetes of the young Genes From Text Documents
7.	MS	Association Study and Computational Analysis of TGFB1& FGFR2 Polymorphism in correlation to Breast Cancer Susceptibility in Pakistani Women
8.	MS	Insilico Analysis of CRBN and GRIK2 Gene Implicated in Nonsyndromic Autosomal Recessive Mental Retardation (ARNSMR)
9.	MS	Structural Based Virtual Screening of Novel Inhibitors of Human Papillomavirus-16 E6 Protein and Optimization through Molecular Dynamic Simulation.
10.	MS	Impact of Normalization Techniques on Downstream Analysis of Differentialy Expressed Gene Data
11.	MS	Identification and Classification of Asthma Related Risk Factors and Symptoms By Using Computational Approach.
12.	MS	Computational assay for epitope Based peptide designing of ebola Virus
13.	MS	Computer Aided drug designing of hereditary angiodema by using data mining approach
14.	MS	Comparative Analysis of Insilico Classification Techniques to Classify SGLT2 Inhibitors (2015)
15.	MS	Computational assay for drug designing of Antiphospholipd Syndrome. (2016)
16.	MS	Mathematical Modeling of E6 Protein of Human Papiloma Virus
17.	MS	P53 Revival Using System Oriented Dosage Design Targeting MDM2. (2017)
18.	MS	Integrated Pathway Mapping of Renal Cell Carcinoma from Biological Resources (2013)

JOURNAL PUBLICATIONS
1.	E. Dilshad, F. Mehmood, R. Tariq, A. Munir, and S. Fazal, “Chemical constituents of artemisia annua are potent inhibitors of alpha-amylase in type ii diabetes,” Life and Science, vol. 3, no. 1, pp. 10–10, 2022.
2.	E. Dilshad, E. Idrees, M., Sajid, B., Munir, a., and Fazal S. 2022. Non-Toxic Flavonoids of Artemisia annua can be used as Anti-Cancer Compounds: A Computational Analysis: Flavonoids of Artemisia annua for Cancer Treatment. Life and Science. Vol 3 No 4.
3.	Sajid, Aimen, Saeed, Muhammad S.; Malik, Rabbiah Manzoor; Fazal, Sahar; Malik, Shaukat; Kamal, Mohammad Amjad. 2022. Prediction of Secondary and Tertiary Structure and Docking of Rb1WT and Rb1R661W Proteins. Volume 11, Number 1, 2022, pp. 71-85(15)
4.	Mandour, N. S., Ren, S. X., Qiu, B. L. and Fazal, S. 2003. Effect of extraction from nymphs, exuviae and adults of Bemisia tabaci B biotype on behaviour of Encarsia bimaculata Heraty et Polaszek (Hymenoptera: Aphelinidae). Acta Entomologica Sinica. 46: 745-748.
5.	Fazal, S., Ren, S. X. 2003. Interaction of Serangium japonicum. (Coleoptera: Coccinelidae), an obligate predator of whitefly with immature stages of Eretmocerus sp. (Hymenoptera: Aphelinidae) within whitefly host (Homoptera: Aleyrodidae). Asain Journal of Plant Sciences. 3: 243-246.
6.	Sualeha K., Ana S., Sahar F., S. and Atif J., A.2010. Predoms: A Computational Toolkit Developed to Perform Prediction of Domains from Sequence. World Applied Sciences Journal 8 (Special Issue of Biotechnology & Genetic Engineering): 44-46.
7.	Zhen H., Sahar F. Shunxiang R., Shaukat A. 2010. Effect of Isaria fumosoroseus on Eretmocerus sp. nr. furuhashii (Hymenoptera: Aphelinidae), a Parasitoid of Bemisia tabaci (Hemiptera: Aleyrodidae). Pakistan Journal of Zoology; Vol. 42 Issue 2, p121
8.	Attiya K., Sahar F., Ismail M., Qasir M. and Amara J. 2011. Linkage analysis of first six MODY genes to know loci and screening of three most prevalent MODY genes in Pakistani population. International Journal of Genetics. Vol. 3, Issue 1, PP-35-46
9.	Kanwal, A., Fazal, S., Ismail, M., & Naureen, N. (2011). A narrative insight to maturity-onset diabetes of the young. Clinical Reviews and Opinions, 3(1), 6-13.
10.	Yadish B. K., M., Sahar F., and Hamid R. 2011. Bioinformatics Approaches for Devising Antiviral /Therapeutic Agent Against Influenze. Int. Res. J. Biochem. Bioinform. 1(7): 168-177.
11.	Raisa B., and Sahar F., Hamid R., Mohammad H. K., 2011. miRNAs; SMALL BUT DEADLY”,. African Journal of Biotechnology. 10(47), pp. 9542-9548
12.	Attiya, K., Sahar, F., Ismail, M., and Nighat, N. 2011: A narrative insight to Maturity onset diabetes of the young; International Journal of Clinical Reviews and Opinions. 3(1), pp. 6-13
13	Sarfraz A. S., Ali H. S., Sahar F., Mushtaq A. S., Syed Muhammad Z. and Muhammad A.. 2012. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab. (Lepidoptera: Noctuidae). Journal of Pest Science. 85(1), 153-162
14.	Attiya K., Sahar F. 2012. Maturity-onset Diabetes of the Young (MODY) Genes: Literature Review. Clinical Practice.1 (1): 4-11
15.	Shad, S. A., Sayyed, A. H., Fazal, S., Saleem, M. A., Zaka, S. M., & Ali, M. (2012). Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab.(Lepidoptera: Noctuidae). Journal of pest science, 85(1), 153-162.
16.	Samina B., Shumaila B. A., Sahar F., and Asif M. 2013. Generation of a 3D model for human cereblon using comparative modeling. Journal of Bioinformatics and Sequence Analysis. 5(1): 10-15.
17.	M. H. Khan, Sahar F., Raisa B. and Hamid R. 2013. A miracle if restored, p53. African Journal of Biotechnology. 12(24), pp. 3745-3751
18.	Attiya K., Sohail A., Sahar F and M. Naeem. 2013. Linkage analysis and subgroup discovery from text documents. Professional Medical Journal. 20 (4):623-633.
19.	Kanwal A, Fazal S, Asghar S, Naeem M. Subgroup discovery of MODY genes from text documents. 2013. Professional Med J; 20(5): 644-652.
20.	Khan, M. T., and Fazal, S. Cyp3a5 polymorphism and the risk of Cancer: a metaanalysis. 2014. European Scientific Journal. .10, (30). 389-398
21.	Haseeb, M, Vaqar, S, Fazal, S, Khalil, A. 2014. Ligand based pharmacophore development for colorectal cancer drugs. Professional Medical Journal. 21(5): 856-853.
22.	Uzma Shaukat, Mehwish Toor, Bilal Ahmad, Sahar Fazal and Nasir Mehmood. Genetic and Computational Analysis of Tgfb1 & Fgfr2 Polymorphism in Correlation to Breast Cancer Susceptibility in Pakistani Women Cancer Science & Therapy 2014, 6:11
23.	Zeb, S., Rehman, S., Khan, M. S., Fazal, S., & Hussain, S. (2014). Journal of Rashid Latif Medical College Review. Journal of Rashid Latif Medical College, 1, 01-03.
24.	M Nisar, N Noureen, S Fazal, MA Qadir. 2015. MCaVoH: A toolkit for mining, classification and visualization of human microbiota. Journal of microbiological methods 117, 28-35
25.	Azam, S., Fazal., and Munir A. 2015. Repositioning of Methotrexate to Cure Mutations of DYR, TYMS and PURA Gene, Bleomycin in the Treatment of Mutant DNA, TOPa, POLa, and RIR Genes. Merit Res. J. Med. Sci. 3 (7), 249-255
26.	Haseeb, M., Fazal, S., and Khattak, F. 2015. Journal of Chemical and Pharmaceutical Research 7 (5), 1136-1146
27.	Khan, M. T., Afzal, S., Rehman, A. U., and Zeb, T. Interleukin 10 (IL-10) promoter-1082 A> G polymorphism and risk of cancer: Meta-analysis. Advancements in Life Sciences 2 (2), 67-73
28.	Khan, M. S. , and Fazal, S. 2015. Advanced Modelling and Functional Characterization of B2 Bradykinin Receptor. Int. J. Bioautomation 19 (2), 123-134
29.	Noureen, N., Touseef, M., Fazal, S., & Qadir, M. A. (2015). ChromClust: A semi-supervised chromatin clustering toolkit for mining histone modifications interplay. Genomics, 106(6), 355-359.
30.	Tabassum, R., Haseeb, M., & Fazal, S. (2016). Structure Prediction of Outer Membrane Protease Protein of Salmonella typhimurium Using Computational Techniques. International Journal Bioautomation, 20(1).
31.	Azam, S. , Munir, A, Khan, M.S., Fazal, S., Mehmood, A., Ali, S., and Hussain, S. 2017. In-Silico Identification of Novel Resistant Genes for Fungal Pathogen Fusarium oxysporum f. sp. cubense Race 4: Causative Agent of Banana Vascular Wilt Disease. J Plant Biochem Physiol 2017, 5:1
32.	Munir A., Azam, S. , Fazal, S., Khan, Z., Mehmood, A. In silico Repositioning of Alendronate and Cytarabine Drugs to Cure Mutations of FPPS, HAP,PTPRS, PTPRE, PTN4, GGPPS Gene and Mutant DNA, DPOLB, TOP2a, DPOLA, DNMT, RNA, TYSY, RIR, Genes Int. J. Bioautomation, Vol. 20(3), 317-328
33.	Munir, A., Azam, S., Manzoor, M., Mehmood, A., Mujtaba, S. G, Fazal, S. 2016. In-silico epitope based vaccine an excellent solution against Marburg virus. Journal of Innovation in Pharmaceuticals and Biological Sciences. Volume: 03. pp:61-66.
34.	Haseeb, M., Azam, S., Bhatti, A. I., Azam, R., Mukhtar Ullah, Fazal, S. 2017. On p53 revival using system oriented drug dosage design. J. Theoretical Biology. Pp 53-57
35.	Khattak, F., Haseeb, M., Fazal, S., Bhatti, A. I., and Mukhtar Ulla. 2017. Mathematical Modeling of E6-p53 interactions in Cervical Cancer. Asian Pac J Cancer Prev. 18(4): 1057–1061
36	Noureen, N., Zohaib, H., M., Abdul Qadir, M., Fazal, S. 2017. ChromBiSim: Interactive chromatin biclustering using a simple approach. Genomics. Vol. 109. pp:353-361
37.	Azam, M., Ullah, M., Fazal, S., & Bhatti, A. I. (2017). System Based Strategies for p53 Recovery. IET Systems Biology.
38.	Kanwal, A., and Fazal, S. 2018. Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis. Gene. Vol. 638. Pp 41-51
39.	Noureen, N., Fazal, S., M.. Abdul Qadir, Afzal, M. T. (2018). HCVS: Pinpointing Chromatin States through Hierarchical Clustering and Visualization Scheme. Current Bioinformatic. Vol. 13.
40.	Munir, A., Azam, S., Aslam, S., Mahmood, A., Shah, G. M., Amjad, S., Younis, M., Fazal, S. 2018. Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions.12: 1-5
41.	Munir, A., Azam, S., Fazal, S. and Bhatti, A.I.2018. Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs. Journal of Theoretical Biology. 451, 1-9

CONFERENCE PUBLICATIONS
1.	Fazal, S., Ren, S. X. 2004. Application of Eretmocerus sp., Serangium japonicum combined with buprofezin against B biotype Bemisia tabaci. International Plant Protection Congress. Bejing, China, 11-16 May.
2.	Nasreen, A., Fareed, S., Cheema, G. M., Fazal, S. and Saleem, M. A. 2005. Effect of different insecticides on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.
3.	Nasreen, A., Cheema, G. M., Fazal, S. and Hanife, K. 2005. Effect of different storage temperatures on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.
4.	Sayyab, S., Nadeem, A., Fazal, S. BVirusGS: DNA Analysis Toolkit for Begomovirus Genome Analysis, 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.
5.	Noureen, N., Kalsoom, N., Fuents, A., Fazal, S., and Malik, S. I. Functional and Promoter Enrichment Based Analysis of Biclustering Algorithms Using Gene Expression Data of Yeast. 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.
6.	Aziz SE, Fazal S, Hussain S and Rashid H , “Detection of relationship between breast cancer and ovarian cancer through network analysis.”, 2nd conference on emerging trends in Bioinformatics: M.A.J.U Islamabad, Pages: 19, MAJU Islamabad, 2014.
7.	Sharif, M. N., Bhatti, A. I., & Fazal, S. (2017, December). Observer design and analysis of wnt-cell cycle joint pathway. In Control Conference (ASCC), 2017 11th Asian (pp. 1470-1475). IEEE.
8.	Bhatti, A. I., Haseeb, M., Azam, S., Fazal, S., & Ullah, M. (2017, May). State feedback based intervention design in Wnt and cell cycle network. In American Control Conference (ACC), 2017 (pp. 4242-4247). IEEE.

POSTER PRESENTATIONS
1.	Fazal, S., Jones, C., Crickmore, N. 20kb DNA- What is it Doing in Bt Crystals. Presented in International Society of Invertebrate Pathology (SIP) and COST organized at Warwick, UK August, 2-7, 2008.
2.	Noureen, N., Kalsoom, N., Alberto de la, F., Fazal, S. Analysis of gene expression using biclustering algorithms. Second National Conference on Health biotechnology held on 27th -28th May, 2008
3.	Zahra, S., Fazal, S., Sayyed, A., H. Repercussion of Sodium Calcium/Potassium Channels In Development of Insecticides Resistance. Conference on Bioinformatics to Systems Biology, July 14, 2008 (BSB ’08).
4.	Tanveer, H., Fatima, H., Fazal, S. Multi Scale Simulation of Cell proteins and their role in Cell Signaling. 2nd Conference in Emerging Trends in Bioinformatics and Computational Biology. June 7, 2014.
5.	Noureen, M., Sati, M., Fazal, S. Visualization and Mining of Human Microbiota Using Computational Techniques. 2nd Conference in Emerging Trends in Bioinformatics and Computational Biology. June 7, 2014.
6.	Zulifqar, A., Farwa, A., Fazal, S. Epigenetic Data Analysis With Computational Approach. 2nd Conference in Emerging Trends in Bioinformatics and Computational Biology.
7.	Shahid, A., Rehman, O., Masood, N., and Fazal, S. Tool for biological knowledge: integration, analysis and visualization of human pathogenic bacteria. 3rd international conference on emerging trends in bioinformatics and biosciences. MAJU. 3, Oct, 2015.
8.	Farhan, A., Masood, N., and Fazal, S. Computaional analysis of T-wave alternans on surface ECG to predict the future Arrhythmia. 3rd international conference on emerging trends in bioinformatics and biosciences. MAJU. 3, Oct, 2015.
9.	Mazhar, A., Ashraf, S., Nadeem, A., and Fzala, S. Arabidopsis pathway inference of metabolic and gene regulatory network at cellular level. 3rd international conference on emerging trends in bioinformatics and biosciences. MAJU. 3, Oct, 2015.

Our Team

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