Dr. Sahar Fazal

PROFILE SUMMARY

Dr. Sahar Fazal is a Professor at department of Bioinformatics and Biosciences. Since 2005, Dr. Sahar Fazal has been actively contributing to CUST. She earned her PhD in Molecular Entomology from South China Agriculture University, Guangzhou, China. Following that, she pursued her Post doc in Biochemistry and Molecular Genetics at the University of Sussex, England. For over a decade, she has been engaged in the field of education, and her teaching abilities are well-received by students. Dr. Sahar’s research focuses on Bioinformatics, Systems Biology, Entomology, Microbiology and Phylogenetics. She has established international connections with various universities globally. Her scientific findings have been published in well-regarded international journals and presented at diverse international forums. Additionally, she serves as a reviewer for several international journals and has authored multiple book chapters.

QUALIFICATION
PhD	Applied Entomology	South China Agriculture University, Guangzhou, People Republic of China	2004
MSc	Applied Entomology	University of Agriculture Faisalabad, Pakistan	1998

TEACHING EXPERIENCE
Professor	Capital University of Science and Technology, Islamabad	Since – 2021
Associate Professor	Mohammad Ali Jinnah University, Islamabad	2012 – 2020
Assistant Professor	Mohammad Ali Jinnah University, Islamabad	2005 – 2012

RESEARCH AREAS / INTERESTS
1.	Phylogenetics
2.	Protein Interactions
3.	Modeling
4.	Pathways

RESEARCH SUPERVISION
1.	PhD	Genome wide mapping of chromatin states based on histone combinatorics for determination of epigenetic expression (2016).
2.	PhD	Construction Of Biological Association Network For Connected Components Analysis Using Graph Theory
3.	PhD	Elastic Network Modelling of Virus Protein Interactions.
4.	MS	Linkage Analysis and Subgroup Discovery of Maturity-onset Diabetes of the young Genes From Text Documents
5.	MS	Association Study and Computational Analysis of TGFB1& FGFR2 Polymorphism in correlation to Breast Cancer Susceptibility in Pakistani Women
6.	MS	Insilico Analysis of CRBN and GRIK2 Gene Implicated in Nonsyndromic Autosomal Recessive Mental Retardation (ARNSMR)
7.	MS	Structural Based Virtual Screening of Novel Inhibitors of Human Papillomavirus-16 E6 Protein and Optimization through Molecular Dynamic Simulation.
8.	MS	Impact of Normalization Techniques on Downstream Analysis of Differentialy Expressed Gene Data
9.	MS	Identification and Classification of Asthma Related Risk Factors and Symptoms By Using Computational Approach.
10.	MS	Computational assay for epitope Based peptide designing of ebola Virus
11.	MS	Computer Aided drug designing of hereditary angiodema by using data mining approach
12.	MS	Comparative Analysis of Insilico Classification Techniques to Classify SGLT2 Inhibitors (2015)
13.	MS	Computational assay for drug designing of Antiphospholipd Syndrome. (2016)
14.	MS	Mathematical Modeling of E6 Protein of Human Papiloma Virus
15.	MS	P53 Revival Using System Oriented Dosage Design Targeting MDM2. (2017)
16.	MS	Integrated Pathway Mapping of Renal Cell Carcinoma from Biological Resources (2013)

SR.	JOURNAL PUBLICATIONS	YEAR
1	E. Dilshad, F. Mehmood, R. Tariq, A. Munir, and S. Fazal, “Chemical constituents of artemisia annua are potent inhibitors of alpha-amylase in type ii diabetes,” Life and Science, vol. 3, no. 1, pp. 10–10	2022
2	E. Dilshad, E. Idrees, M., Sajid, B., Munir, a., and Fazal S. Non-Toxic Flavonoids of Artemisia annua can be used as Anti-Cancer Compounds: A Computational Analysis: Flavonoids of Artemisia annua for Cancer Treatment. Life and Science. Vol 3 No 4	2022
3	Sajid, Aimen, Saeed, Muhammad S.; Malik, Rabbiah Manzoor; Fazal, Sahar; Malik, Shaukat; Kamal, Mohammad Amjad. Prediction of Secondary and Tertiary Structure and Docking of Rb1WT and Rb1R661W Proteins. Volume 11, Number 1, 2022, pp. 71-85(15)	2022
4	Mandour, N. S., Ren, S. X., Qiu, B. L. and Fazal, S. Effect of extraction from nymphs, exuviae and adults of Bemisia tabaci B biotype on behaviour of Encarsia bimaculata Heraty et Polaszek (Hymenoptera: Aphelinidae). Acta Entomologica Sinica. 46: 745-748	2003
5	Fazal, S., Ren, S. X. Interaction of Serangium japonicum. (Coleoptera: Coccinelidae), an obligate predator of whitefly with immature stages of Eretmocerus sp. (Hymenoptera: Aphelinidae) within whitefly host (Homoptera: Aleyrodidae). Asain Journal of Plant Sciences. 3: 243-246	2003
6	Sualeha K., Ana S., Sahar F., S. and Atif J., A. Predoms: A Computational Toolkit Developed to Perform Prediction of Domains from Sequence. World Applied Sciences Journal 8 (Special Issue of Biotechnology & Genetic Engineering): 44-46	2010
7	Zhen H., Sahar F. Shunxiang R., Shaukat A. Effect of Isaria fumosoroseus on Eretmocerus sp. nr. furuhashii (Hymenoptera: Aphelinidae), a Parasitoid of Bemisia tabaci (Hemiptera: Aleyrodidae). Pakistan Journal of Zoology; Vol. 42 Issue 2, p121	2010
8	Attiya K., Sahar F., Ismail M., Qasir M. and Amara J. Linkage analysis of first six MODY genes to know loci and screening of three most prevalent MODY genes in Pakistani population. International Journal of Genetics. Vol. 3, Issue 1, PP-35-46	2011
9	Kanwal, A., Fazal, S., Ismail, M., & Naureen, N. (2011). A narrative insight to maturity-onset diabetes of the young. Clinical Reviews and Opinions, 3(1), 6-13	2011
10	Yadish B. K., M., Sahar F., and Hamid R. 2011. Bioinformatics Approaches for Devising Antiviral /Therapeutic Agent Against Influenze. Int. Res. J. Biochem. Bioinform. 1(7): 168-177	2011
11	Raisa B., and Sahar F., Hamid R., Mohammad H. K., 2011. miRNAs; SMALL BUT DEADLY”,. African Journal of Biotechnology. 10(47), pp. 9542-9548	2011
12	Attiya, K., Sahar, F., Ismail, M., and Nighat, N. 2011: A narrative insight to Maturity onset diabetes of the young; International Journal of Clinical Reviews and Opinions. 3(1), pp. 6-13	2012
13	Sarfraz A. S., Ali H. S., Sahar F., Mushtaq A. S., Syed Muhammad Z. and Muhammad A.. 2012. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab. (Lepidoptera: Noctuidae). Journal of Pest Science. 85(1), 153-162	2012
14	Attiya K., Sahar F. Maturity-onset Diabetes of the Young (MODY) Genes: Literature Review. Clinical Practice.1 (1): 4-11	2012
15	Shad, S. A., Sayyed, A. H., Fazal, S., Saleem, M. A., Zaka, S. M., & Ali, M. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab.(Lepidoptera: Noctuidae). Journal of pest science, 85(1), 153-162	2012
16	Samina B., Shumaila B. A., Sahar F., and Asif M. Generation of a 3D model for human cereblon using comparative modeling. Journal of Bioinformatics and Sequence Analysis. 5(1): 10-15	2013
17	M. H. Khan, Sahar F., Raisa B. and Hamid R. A miracle if restored, p53. African Journal of Biotechnology. 12(24), pp. 3745-3751	2013
18	Attiya K., Sohail A., Sahar F and M. Naeem. Linkage analysis and subgroup discovery from text documents. Professional Medical Journal. 20 (4):623-633	2013
19	Kanwal A, Fazal S, Asghar S, Naeem M. Subgroup discovery of MODY genes from text documents. 2013. Professional Med J; 20(5): 644-652	2013
20	Khan, M. T., and Fazal, S. Cyp3a5 polymorphism and the risk of Cancer: a metaanalysis. European Scientific Journal. .10, (30). 389-398	2014
21	Haseeb, M, Vaqar, S, Fazal, S, Khalil, A. Ligand based pharmacophore development for colorectal cancer drugs. Professional Medical Journal. 21(5): 856-853	2014
22	Uzma Shaukat, Mehwish Toor, Bilal Ahmad, Sahar Fazal and Nasir Mehmood. Genetic and Computational Analysis of Tgfb1 & Fgfr2 Polymorphism in Correlation to Breast Cancer Susceptibility in Pakistani Women Cancer Science & Therapy, 6:11	2014
23	Zeb, S., Rehman, S., Khan, M. S., Fazal, S., & Hussain, S. (2014). Journal of Rashid Latif Medical College Review. Journal of Rashid Latif Medical College, 1, 01-03	2014
24	M Nisar, N Noureen, S Fazal, MA Qadir. MCaVoH: A toolkit for mining, classification and visualization of human microbiota. Journal of microbiological methods 117, 28-35	2015
25	Azam, S., Fazal., and Munir A. Repositioning of Methotrexate to Cure Mutations of DYR, TYMS and PURA Gene, Bleomycin in the Treatment of Mutant DNA, TOPa, POLa, and RIR Genes. Merit Res. J. Med. Sci. 3 (7), 249-255	2015
26	Haseeb, M., Fazal, S., and Khattak, F. 2015. Journal of Chemical and Pharmaceutical Research 7 (5), 1136-1146	2015
27	Khan, M. T., Afzal, S., Rehman, A. U., and Zeb, T. Interleukin 10 (IL-10) promoter-1082 A> G polymorphism and risk of cancer: Meta-analysis. Advancements in Life Sciences 2 (2), 67-73
28	Khan, M. S. , and Fazal, S. Advanced Modelling and Functional Characterization of B2 Bradykinin Receptor. Int. J. Bioautomation 19 (2), 123-134	2015
29	Noureen, N., Touseef, M., Fazal, S., & Qadir, M. A. (2015). ChromClust: A semi-supervised chromatin clustering toolkit for mining histone modifications interplay. Genomics, 106(6), 355-359	2015
30	Tabassum, R., Haseeb, M., & Fazal, S. (2016). Structure Prediction of Outer Membrane Protease Protein of Salmonella typhimurium Using Computational Techniques. International Journal Bioautomation, 20(1)	2016
31	Azam, S. , Munir, A, Khan, M.S., Fazal, S., Mehmood, A., Ali, S., and Hussain, S. In-Silico Identification of Novel Resistant Genes for Fungal Pathogen Fusarium oxysporum f. sp. cubense Race 4: Causative Agent of Banana Vascular Wilt Disease. J Plant Biochem Physiol 2017, 5:1	2017
32	Munir A., Azam, S. , Fazal, S., Khan, Z., Mehmood, A. In silico Repositioning of Alendronate and Cytarabine Drugs to Cure Mutations of FPPS, HAP,PTPRS, PTPRE, PTN4, GGPPS Gene and Mutant DNA, DPOLB, TOP2a, DPOLA, DNMT, RNA, TYSY, RIR, Genes Int. J. Bioautomation, Vol. 20(3), 317-328
33	Munir, A., Azam, S., Manzoor, M., Mehmood, A., Mujtaba, S. G, Fazal, S. In-silico epitope based vaccine an excellent solution against Marburg virus. Journal of Innovation in Pharmaceuticals and Biological Sciences. Volume: 03. pp:61-66	2016
34	Haseeb, M., Azam, S., Bhatti, A. I., Azam, R., Mukhtar Ullah, Fazal, S. On p53 revival using system oriented drug dosage design. J. Theoretical Biology. Pp 53-57	2017
35	Khattak, F., Haseeb, M., Fazal, S., Bhatti, A. I., and Mukhtar Ulla. Mathematical Modeling of E6-p53 interactions in Cervical Cancer. Asian Pac J Cancer Prev. 18(4): 1057–1061	2017
36	Noureen, N., Zohaib, H., M., Abdul Qadir, M., Fazal, S. ChromBiSim: Interactive chromatin biclustering using a simple approach. Genomics. Vol. 109. pp:353-361	2017
37	Azam, M., Ullah, M., Fazal, S., & Bhatti, A. I. (2017). System Based Strategies for p53 Recovery. IET Systems Biology	2017
38	Kanwal, A., and Fazal, S. Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis. Gene. Vol. 638. Pp 41-51	2018
39	Noureen, N., Fazal, S., M.. Abdul Qadir, Afzal, M. T. (2018). HCVS: Pinpointing Chromatin States through Hierarchical Clustering and Visualization Scheme. Current Bioinformatic. Vol. 13	2018
40	Munir, A., Azam, S., Aslam, S., Mahmood, A., Shah, G. M., Amjad, S., Younis, M., Fazal, S. Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions.12: 1-5	2018
41	Munir, A., Azam, S., Fazal, S. and Bhatti, A.I. Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs. Journal of Theoretical Biology. 451, 1-9	2018

SR.	CONFERENCE PUBLICATIONS	YEAR
1	Fazal, S., Ren, S. X. 2004. Application of Eretmocerus sp., Serangium japonicum combined with buprofezin against B biotype Bemisia tabaci. International Plant Protection Congress. Bejing, China, 11-16 May.	2004
2	Nasreen, A., Fareed, S., Cheema, G. M., Fazal, S. and Saleem, M. A. 2005. Effect of different insecticides on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.	2005
3	Nasreen, A., Cheema, G. M., Fazal, S. and Hanife, K. 2005. Effect of different storage temperatures on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.	2005
4	Sayyab, S., Nadeem, A., Fazal, S. BVirusGS: DNA Analysis Toolkit for Begomovirus Genome Analysis, 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.	2009
5	Noureen, N., Kalsoom, N., Fuents, A., Fazal, S., and Malik, S. I. Functional and Promoter Enrichment Based Analysis of Biclustering Algorithms Using Gene Expression Data of Yeast. 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.	2009
6	Aziz SE, Fazal S, Hussain S and Rashid H , “Detection of relationship between breast cancer and ovarian cancer through network analysis.”, 2nd conference on emerging trends in Bioinformatics: M.A.J.U Islamabad, Pages: 19, MAJU Islamabad, 2014.	2009
7	Sharif, M. N., Bhatti, A. I., & Fazal, S. (2017, December). Observer design and analysis of wnt-cell cycle joint pathway. In Control Conference (ASCC), 2017 11th Asian (pp. 1470-1475). IEEE.	2017
8	Bhatti, A. I., Haseeb, M., Azam, S., Fazal, S., & Ullah, M. (2017, May). State feedback based intervention design in Wnt and cell cycle network. In American Control Conference (ACC), 2017 (pp. 4242-4247). IEEE.	2017

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