Dr. Sahar Fazal

Professor/Dean Faculty of Health & Life Sciences

Dr. Sahar Fazal is a Professor at department of Bioinformatics and Biosciences. Since 2005, Dr. Sahar Fazal has been actively contributing to CUST. She earned her PhD in Molecular Entomology from South China Agriculture University, Guangzhou, China. Following that, she pursued her Post doc in Biochemistry and Molecular Genetics at the University of Sussex, England. For over a decade, she has been engaged in the field of education, and her teaching abilities are well-received by students. Dr. Sahar’s research focuses on Bioinformatics, Systems Biology, Entomology, Microbiology and Phylogenetics. She has established international connections with various universities globally. Her scientific findings have been published in well-regarded international journals and presented at diverse international forums. Additionally, she serves as a reviewer for several international journals and has authored multiple book chapters.

PhD Applied Entomology South China Agriculture University, Guangzhou, People Republic of China 2004
MSc Applied Entomology University of Agriculture Faisalabad, Pakistan 1998
Professor Capital University of Science and Technology, Islamabad Since – 2021
Associate Professor Mohammad Ali Jinnah University, Islamabad 2012 – 2020
Assistant Professor Mohammad Ali Jinnah University, Islamabad 2005 – 2012
1. Phylogenetics
2. Protein Interactions
3. Modeling
4. Pathways
1. PhD Genome wide mapping of chromatin states based on histone combinatorics for determination of epigenetic expression (2016).
2. PhD Construction Of Biological Association Network For Connected Components Analysis Using Graph Theory
3. PhD Elastic Network Modelling of Virus Protein Interactions.
4. MS Linkage Analysis and Subgroup Discovery of Maturity-onset Diabetes of the young Genes From Text Documents
5. MS Association Study and Computational Analysis of TGFB1& FGFR2 Polymorphism in correlation to Breast Cancer Susceptibility in Pakistani Women
6. MS Insilico Analysis of CRBN and GRIK2 Gene Implicated in Nonsyndromic Autosomal Recessive Mental Retardation (ARNSMR)
7. MS Structural Based Virtual Screening of Novel Inhibitors of Human Papillomavirus-16 E6 Protein and Optimization through Molecular Dynamic Simulation.
8. MS Impact of Normalization Techniques on Downstream Analysis of Differentialy Expressed Gene Data
9. MS Identification and Classification of Asthma Related Risk Factors and Symptoms By Using Computational Approach.
10. MS Computational assay for epitope Based peptide designing of ebola Virus
11. MS Computer Aided drug designing of hereditary angiodema by using data mining approach
12. MS Comparative Analysis of Insilico Classification Techniques to Classify SGLT2 Inhibitors (2015)
13. MS Computational assay for drug designing of Antiphospholipd Syndrome. (2016)
14. MS Mathematical Modeling of E6 Protein of Human Papiloma Virus
15. MS P53 Revival Using System Oriented Dosage Design Targeting MDM2. (2017)
16. MS Integrated Pathway Mapping of Renal Cell Carcinoma from Biological Resources (2013)

1E. Dilshad, F. Mehmood, R. Tariq, A. Munir, and S. Fazal, “Chemical constituents of artemisia annua are potent inhibitors of alpha-amylase in type ii diabetes,” Life and Science, vol. 3, no. 1, pp. 10–102022
2E. Dilshad, E. Idrees, M., Sajid, B., Munir, a., and Fazal S. Non-Toxic Flavonoids of Artemisia annua can be used as Anti-Cancer Compounds: A Computational Analysis: Flavonoids of Artemisia annua for Cancer Treatment. Life and Science. Vol 3 No 42022
3Sajid, Aimen, Saeed, Muhammad S.; Malik, Rabbiah Manzoor; Fazal, Sahar; Malik, Shaukat; Kamal, Mohammad Amjad. Prediction of Secondary and Tertiary Structure and Docking of Rb1WT and Rb1R661W Proteins. Volume 11, Number 1, 2022, pp. 71-85(15)2022
4Mandour, N. S., Ren, S. X., Qiu, B. L. and Fazal, S. Effect of extraction from nymphs, exuviae and adults of Bemisia tabaci B biotype on behaviour of Encarsia bimaculata Heraty et Polaszek (Hymenoptera: Aphelinidae). Acta Entomologica Sinica. 46: 745-7482003
5Fazal, S., Ren, S. X. Interaction of Serangium japonicum. (Coleoptera: Coccinelidae), an obligate predator of whitefly with immature stages of Eretmocerus sp. (Hymenoptera: Aphelinidae) within whitefly host (Homoptera: Aleyrodidae). Asain Journal of Plant Sciences. 3: 243-2462003
6Sualeha K., Ana S., Sahar F., S. and Atif J., A. Predoms: A Computational Toolkit Developed to Perform Prediction of Domains from Sequence. World Applied Sciences Journal 8 (Special Issue of Biotechnology & Genetic Engineering): 44-462010
7Zhen H., Sahar F. Shunxiang R., Shaukat A. Effect of Isaria fumosoroseus on Eretmocerus sp. nr. furuhashii (Hymenoptera: Aphelinidae), a Parasitoid of Bemisia tabaci (Hemiptera: Aleyrodidae). Pakistan Journal of Zoology; Vol. 42 Issue 2, p1212010
8Attiya K., Sahar F., Ismail M., Qasir M. and Amara J. Linkage analysis of first six MODY genes to know loci and screening of three most prevalent MODY genes in Pakistani population. International Journal of Genetics. Vol. 3, Issue 1, PP-35-462011
9Kanwal, A., Fazal, S., Ismail, M., & Naureen, N. (2011). A narrative insight to maturity-onset diabetes of the young. Clinical Reviews and Opinions, 3(1), 6-132011
10Yadish B. K., M., Sahar F., and Hamid R. 2011. Bioinformatics Approaches for Devising Antiviral /Therapeutic Agent Against Influenze. Int. Res. J. Biochem. Bioinform. 1(7): 168-1772011
11Raisa B., and Sahar F., Hamid R., Mohammad H. K., 2011. miRNAs; SMALL BUT DEADLY”,. African Journal of Biotechnology. 10(47), pp. 9542-95482011
12Attiya, K., Sahar, F., Ismail, M., and Nighat, N. 2011: A narrative insight to Maturity onset diabetes of the young; International Journal of Clinical Reviews and Opinions. 3(1), pp. 6-132012
13Sarfraz A. S., Ali H. S., Sahar F., Mushtaq A. S., Syed Muhammad Z. and Muhammad A.. 2012. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab. (Lepidoptera: Noctuidae). Journal of Pest Science. 85(1), 153-1622012
14Attiya K., Sahar F. Maturity-onset Diabetes of the Young (MODY) Genes: Literature Review. Clinical Practice.1 (1): 4-112012
15Shad, S. A., Sayyed, A. H., Fazal, S., Saleem, M. A., Zaka, S. M., & Ali, M. Field evolved resistance to carbamates, organophosphates, pyrethroids, and new chemistry insecticides in Spodoptera litura Fab.(Lepidoptera: Noctuidae). Journal of pest science, 85(1), 153-1622012
16Samina B., Shumaila B. A., Sahar F., and Asif M. Generation of a 3D model for human cereblon using comparative modeling. Journal of Bioinformatics and Sequence Analysis. 5(1): 10-152013
17M. H. Khan, Sahar F., Raisa B. and Hamid R. A miracle if restored, p53. African Journal of Biotechnology. 12(24), pp. 3745-37512013
18Attiya K., Sohail A., Sahar F and M. Naeem. Linkage analysis and subgroup discovery from text documents. Professional Medical Journal. 20 (4):623-6332013
19Kanwal A, Fazal S, Asghar S, Naeem M. Subgroup discovery of MODY genes from text documents. 2013. Professional Med J; 20(5): 644-6522013
20Khan, M. T., and Fazal, S. Cyp3a5 polymorphism and the risk of Cancer: a metaanalysis. European Scientific Journal. .10, (30). 389-3982014
21Haseeb, M, Vaqar, S, Fazal, S, Khalil, A. Ligand based pharmacophore development for colorectal cancer drugs. Professional Medical Journal. 21(5): 856-8532014
22Uzma Shaukat, Mehwish Toor, Bilal Ahmad, Sahar Fazal and Nasir Mehmood. Genetic and Computational Analysis of Tgfb1 & Fgfr2 Polymorphism in Correlation to Breast Cancer Susceptibility in Pakistani Women Cancer Science & Therapy, 6:112014
23Zeb, S., Rehman, S., Khan, M. S., Fazal, S., & Hussain, S. (2014). Journal of Rashid Latif Medical College Review. Journal of Rashid Latif Medical College, 1, 01-032014
24M Nisar, N Noureen, S Fazal, MA Qadir. MCaVoH: A toolkit for mining, classification and visualization of human microbiota. Journal of microbiological methods 117, 28-352015
25Azam, S., Fazal., and Munir A. Repositioning of Methotrexate to Cure Mutations of DYR, TYMS and PURA Gene, Bleomycin in the Treatment of Mutant DNA, TOPa, POLa, and RIR Genes. Merit Res. J. Med. Sci. 3 (7), 249-2552015
26Haseeb, M., Fazal, S., and Khattak, F. 2015. Journal of Chemical and Pharmaceutical Research 7 (5), 1136-11462015
27Khan, M. T., Afzal, S., Rehman, A. U., and Zeb, T. Interleukin 10 (IL-10) promoter-1082 A> G polymorphism and risk of cancer: Meta-analysis. Advancements in Life Sciences 2 (2), 67-73
28Khan, M. S. , and Fazal, S. Advanced Modelling and Functional Characterization of B2 Bradykinin Receptor. Int. J. Bioautomation 19 (2), 123-1342015
29Noureen, N., Touseef, M., Fazal, S., & Qadir, M. A. (2015). ChromClust: A semi-supervised chromatin clustering toolkit for mining histone modifications interplay. Genomics, 106(6), 355-3592015
30Tabassum, R., Haseeb, M., & Fazal, S. (2016). Structure Prediction of Outer Membrane Protease Protein of Salmonella typhimurium Using Computational Techniques. International Journal Bioautomation, 20(1)2016
31Azam, S. , Munir, A, Khan, M.S., Fazal, S., Mehmood, A., Ali, S., and Hussain, S. In-Silico Identification of Novel Resistant Genes for Fungal Pathogen Fusarium oxysporum f. sp. cubense Race 4: Causative Agent of Banana Vascular Wilt Disease. J Plant Biochem Physiol 2017, 5:12017
32Munir A., Azam, S. , Fazal, S., Khan, Z., Mehmood, A. In silico Repositioning of Alendronate and Cytarabine Drugs to Cure Mutations of FPPS, HAP,PTPRS, PTPRE, PTN4, GGPPS Gene and Mutant DNA, DPOLB, TOP2a, DPOLA, DNMT, RNA, TYSY, RIR, Genes Int. J. Bioautomation, Vol. 20(3), 317-328
33Munir, A., Azam, S., Manzoor, M., Mehmood, A., Mujtaba, S. G, Fazal, S. In-silico epitope based vaccine an excellent solution against Marburg virus. Journal of Innovation in Pharmaceuticals and Biological Sciences. Volume: 03. pp:61-662016
34Haseeb, M., Azam, S., Bhatti, A. I., Azam, R., Mukhtar Ullah, Fazal, S. On p53 revival using system oriented drug dosage design. J. Theoretical Biology. Pp 53-572017
35Khattak, F., Haseeb, M., Fazal, S., Bhatti, A. I., and Mukhtar Ulla. Mathematical Modeling of E6-p53 interactions in Cervical Cancer. Asian Pac J Cancer Prev. 18(4): 1057–10612017
36Noureen, N., Zohaib, H., M., Abdul Qadir, M., Fazal, S. ChromBiSim: Interactive chromatin biclustering using a simple approach. Genomics. Vol. 109. pp:353-3612017
37Azam, M., Ullah, M., Fazal, S., & Bhatti, A. I. (2017). System Based Strategies for p53 Recovery. IET Systems Biology2017
38Kanwal, A., and Fazal, S. Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis. Gene. Vol. 638. Pp 41-512018
39Noureen, N., Fazal, S., M.. Abdul Qadir, Afzal, M. T. (2018). HCVS: Pinpointing Chromatin States through Hierarchical Clustering and Visualization Scheme. Current Bioinformatic. Vol. 132018
40Munir, A., Azam, S., Aslam, S., Mahmood, A., Shah, G. M., Amjad, S., Younis, M., Fazal, S. Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions.12: 1-52018
41Munir, A., Azam, S., Fazal, S. and Bhatti, A.I. Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs. Journal of Theoretical Biology. 451, 1-92018

1Fazal, S., Ren, S. X. 2004. Application of Eretmocerus sp., Serangium japonicum combined with buprofezin against B biotype Bemisia tabaci. International Plant Protection Congress. Bejing, China, 11-16 May.2004
2Nasreen, A., Fareed, S., Cheema, G. M., Fazal, S. and Saleem, M. A. 2005. Effect of different insecticides on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.2005
3Nasreen, A., Cheema, G. M., Fazal, S. and Hanife, K. 2005. Effect of different storage temperatures on the eggs of Chrysopa carnea (Neuroptera: Chrysopidae). Presented in 25th International Zoological Conference.2005
4Sayyab, S., Nadeem, A., Fazal, S. BVirusGS: DNA Analysis Toolkit for Begomovirus Genome Analysis, 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.2009
5Noureen, N., Kalsoom, N., Fuents, A., Fazal, S., and Malik, S. I. Functional and Promoter Enrichment Based Analysis of Biclustering Algorithms Using Gene Expression Data of Yeast. 13th IEEE International Multitopic Conference (INMIC 2009), December 14-15, 2009, Islamabad, Pakistan.2009
6Aziz SE, Fazal S, Hussain S and Rashid H , “Detection of relationship between breast cancer and ovarian cancer through network analysis.”, 2nd conference on emerging trends in Bioinformatics: M.A.J.U Islamabad, Pages: 19, MAJU Islamabad, 2014.2009
7Sharif, M. N., Bhatti, A. I., & Fazal, S. (2017, December). Observer design and analysis of wnt-cell cycle joint pathway. In Control Conference (ASCC), 2017 11th Asian (pp. 1470-1475). IEEE.2017
8Bhatti, A. I., Haseeb, M., Azam, S., Fazal, S., & Ullah, M. (2017, May). State feedback based intervention design in Wnt and cell cycle network. In American Control Conference (ACC), 2017 (pp. 4242-4247). IEEE.2017

Other Members