dr.muzzaffar

Dr. Muzaffar Abbas (PhD SDSU, USA)

Associate Professor
PROFILE SUMMARY

Dr. Abbas completed the PhD degree in Pharmacology under Fulbright Scholarship Program from South Dakota State University, USA, in 2016. He worked at different positions including Lecturer, Assistant Professor, Associate Professor and Head of Basic Medical Sciences Department. Dr. Abbas has broad research interests in the areas of neuroscience, molecular pharmacology and neuropharmacology. His specific field of research focuses on drug discovery and development for neurological disorders including depression, memory, anxiety, opioid tolerance, opioid-induced paradoxical pain, addiction, neuropathic and neuroinflammatory pain in laboratory animal models. He has supervised post-graduate research projects. He remained member of Society for Neuroscience (SFN), USA, American Society for Pharmacology and Experimental Therapeutics (ASPET), USA and American Pain Society (APS), USA. He is life time member of The Rho Chi Honor Society, South Dakota State University, USA.

QUALIFICATION
PhD Pharmacology Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, USA 2016
MPhil Pharmacology Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan. 2009
B.Pharm Pharmaceutical Sciences Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan 2005
TEACHING EXPERIENCE
Associate Professor Capital University of Science and Technology (CUST), Islamabad Since – 2018
Assistant Professor Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 2017 – 2018
Teaching Assistant Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, USA 2012 – 2016
Lecturer Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan 2008 – 2012
Lecturer Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan 2008 – 2008
MANAGEMENT EXPERIENCE
Head of Department Department of Pharmacy, Capital University of Science & Technology, Islamabad Since-July 2018
Head of Department Department of Basic Medical Sciences, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 2017 – 2018
In-charge Post Graduate studies Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 2017 – 2018
MEMBERSHIP OF PROFESSIONAL BODIES
Member Society for Neuroscience (SFN), USA.
Member The Rho Chi Honor Society, South Dakota State University, USA
Member American Society for Pharmacology and Experimental Therapeutics (ASPET), USA.
Member American Pain Society (APS), USA
Member American Academy of Pain Management, USA
Member Member of Fulbright panel for PhD studies
HONORS & AWARDS
1. Fulbright Scholarship for PhD studies
2. Young Investigator Travel Award, 2016 from American Pain Society. USA.
3. First Place Award in 2015 for Graduate Student Senior Category at the 25th Annual Pharmacy Research Presentations at South Dakota State University, USA
4. Vice Chair of the student chapter of American Association of Pharmaceutical Sciences at South Dakota State University; USA (2014-2015).
RESEARCH AREAS / INTERESTS
  1. Drug discovery;
  2. Neurological Disorders;
  3. Anxiety;
  4. Opioid Tolerance;
  5. Neuropathic;
  6. Neuroinflammatory pain in animal models involving Nicotinic acetylcholine receptors;
  7. Opioid receptors;
  8. Peroxisome proliferator-activated receptors (PPARs).
RESEARCH SUPERVISION
1. PhD Synthesis, Characterization, In silico and Pharmacological Investigation of New Benzimidazole Derivatives against Neurodegenerative diseases
2. PhD Pharmacological Studies and Herbal Drug Development of Saussurea lappa, Saussurea heteromalla and Related Species.
3. MPhil Synthesis, Characterization and Pharmacological Evaluation of 5-Substituted Isoxazole-3-Carboxamides
4. MPhil Studies on Neuropharmacological Effects of methoxy benzylidine cyclopentanone
5. MPhil Hepatoprotective Effect of Ginkgo Biloba Extract against Methotrexate Induced Hepatotoxicity in Rats
6. MPhil Synthesis, Pharmacological Investigation and Molecular Docking Studies of 4-Thiazolidinone Derivatives
7. MPhil Neuropharmacological Investigation of Telmisartan against Opioid Dependence and its Correlation in Mesolimbic System
8. MPhil Pharmacological Investigation of Benzimidazole Derivatives against Opioid-Induced Paradoxical Pain in Animal Models
9. MPhil Neuropharmacological effects of 2-[(Pyrrolidin-1-yl)Methyl]-1H-Benzimidazole against Opioid Tolerance during Anticancer-Induced Neuropathic Pain
JOURNAL PUBLICATIONS
1. F. A. Shah, G. Liu, L. T. Al Kury, A. Zeb, M. Abbas, T. Li, X. Yang, F. Liu, Y. Jiang, and S. Li, “Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways”, Frontiers in Pharmacology, vol.10, pp.1-11, 2019.
2. Z. Idris, M. Abbas, H. Nadeem and A. Khan “The benzimidazole derivatives, B1 (N-[(1H-Benzimidazol-2-yl)methyl]-4-methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)methoxy]phenyl}acetamide) attenuate morphine-induced paradoxical pain in mice”, Frontiers in Neuroscience, vol. 13, pp. 1-9, 2019.
3. H. Bibi, H. Nadeem, M. Abbas and M. Arif, “Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives”, BMC Chemistry, vol. 13, no. 6, pp.1-13, 2019.
4. T. Ahmed, A. Khan, M. Abbas, E. R. Filho, Z. Din and A. Khan. “Synthesis, characterization, molecular docking, analgesic, antiplatelet and anticoagulant effects of dibenzylidene ketone derivatives”, Chemistry Central Journal, vol. 12, no. 134, 2018.
5. M. Abbas, S. Alzarea, R. L. Papke, and S. Rahman, “The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice”, Drug Discoveries & Therapeutics, vol. 11, no. 4, pp. 206-211, 2017.
6. N. Islam, M. Abbas, and S. Rahman, “Neuropathic Pain and Lung Delivery of Nanoparticulate Drugs: An Emerging Novel Therapeutic Strategy”. CNS & Neurological Disorders-Drug Targets, vol. 16, pp. 303-310. 2017.
7. M. Abbas, and S. Rahman, “Effects of alpha-7 nicotinic acetylcholine receptor positive allosteric modulator on lipopolysaccharide-induced neuroinflammatory pain in mic”, European Journal of Pharmacology, vol. 783, pp. 85-91, 2016.
8. G. Ali, F. Subhan, M. Abbas, J. Zeb, M. Shahid, and R. D. E. Sewell, “A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin”. Naunyn-Schmiedeberg’s Archives of Pharmacology, vol. 388, no. 11, pp. 1129-1140, 2015.
9. M. Khan, F Subhan, A. Khan, M. Abbas, G. Ali, Khalid Rauf, and A. H. Gilani, “Nature cures nature: Hypericum perforatum attenuates physical withdrawal signs in opium dependent rats”, Pharmaceutical Biology, vol. 52, pp. 586-590. 2014.
10. K. Rauf, F. Subhan, M. Abbas, S. M. Ali, G. Ali, M. Ashfaq, G. Abbas, “Inhibitory effect of bacopasides on spontaneous morphine withdrawal induced depression in mice”, Phytotherapy Research, vol. 28, pp. 937-939, 2014.
11. G. Ali, F. Subhan, N. Islam, I. Khan, K. Rauf, S. Ullah, M. Abbas, and A. Rauf, Input of Isosteric and Bioisosteric Approach in Drug Design. Journal of the Chemical Society of Pakistan, vol. 36, pp. 150-169, 2014.
12. H. Khan, M. Saeed, A. H.Gilani, H. M. Mehmood, N. U. Rehman, N. Muhammad, M. Abbas, and I. Haq, “Bronchodilator activity of aerial parts of Polygonatum verticillatum augmented by anti-inflammatory activity: attenuation of Ca²⁺ channels and lipoxygenase”, Phytotherapy Research, vol. 27, no. 9, pp. 1288-1292, 2013.
13. M. Abbas, F. Subhan, K. Rauf, I. Haq, S. N. Mohani, “The involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri” Iranian Journal of Pharmacology & Therapeutics, vol. 11, no. 1, pp. 15-19, 2012
14. K. Rauf, F. Subhan, M. Abbas, I. Haq, G. Ali, and M. Ayaz, “Effect of acute and sub chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain” African Journal of Pharmacy and Pharmacology, Vol. 6, pp. 2767-2774, 2012.
15. M. Ismail, S. Rahman, A. zada, Roohullah, N. Muhammad, and M. Abbas, “Analgesic, anti GIT motility and toxicological activities of Pistaciai ntegerrima Stewart ex Brandis bark in mice”, Journal of Medicinal Plants Research, Vol. 6, no. 14, pp. 2827-2831, 2012.
16. K. Rauf, F. Subhan, M. Abbas, A. Badshah, I. Ullah, and S. Ullah, “Effect of bacopasides on acquisition and expression of morphine tolerance’, Phytomedicine. vol. 18, pp. 836-842. 2011.
17. M. Abbas, F. Subhan, K. Rauf, M. Khan, and S. N. Mohani. “The involvement of biogenic amines in the antidepressant effect of Bacopa monnieri”, PharmacologyOnline, vol. 1, pp. 112-123, 2011.
18. M. Abbas, F. Subhan, S. N. Mohani, K. Rauf, G. Ali, and M. Khan, “The involvement of opioidergic mechanisms in the activity of Bacopa monnieri extract and its toxicological studies”, African Journal of Pharmacy and Pharmacology, vol. 5, pp. 1120-1124. 2011.
19. S. Rahman, M. Ismail, M. Abbas, and N. Muhammad, “Study of antipyretic activity of Pistacia integerrima Stewart ex Brandis bark in Balb-C mice” Journal of Pharmacy Research, vol. 4, no. 12, pp. 4411-4412, 2011.
20. F. Subhan, M. Abbas, K. Rauf, and A. Baseer, “Anti GIT motility, toxicological and phytochemical studies on Bacopa monnieri”, PharmacologyOnline, vol. 3, pp. 907-950. 2010.
21. F. Subhan, M. Abbas, K. Rauf, M. Arfan, R. D. E. Sewell, and G. Ali, “The role of opioidergic mechanism in the activity of Bacopa monnieri extract against tonic and acute phasic pain modalities”, PharmacologyOnline, vol. 3, pp. 903-914, 2010.
CONFERENCE PUBLICATIONS
1. S. Rahman, and M. Abbas, “Effects of α7 nicotinic receptor positive allosteric modulator on sodium-potassium-chloride co-transporter 1 activation following lipopolysaccharide-induced neuroinflammatory pain in mice”, The FASEB Journal. Vol. 31, no. 1, pp. 812.2, 2017.
2. M. Abbas, and S. Rahman, “Brain alpha-7 nicotinic receptor positive allosteric modulator attenuates mechanical allodynia and hyperalgesia in a mouse model of neuroinflammatory pain” The Journal of Pain. Vol. 17, no. 4, pp. S75, 2016.
3. M. Abbas, and S. Rahman, “Antihyperalgesic and antiallodynic effects of 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c] quinoline-8 sulfonamide in an animal model of neuroinflammatory pain” The FASEB Journal. Vol. 30, pp. 927.1., 2016.
4. M. Abbas, and S. Rahman, “Effects of nicotinic acetylcholine receptor positive allosteric modulator on microglia activation following lipopolysaccharide-induced neuropathic pain” The FASEB Journal, vol. 29, pp. 770.14, 2015.
5. S. Rahman, M. Abbas, Effects of nicotinic acetylcholine receptor positive allosteric modulator in a neuropathic pain model, The FASEB Journal, (2014), 28, 661.10.

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