dr.muzzaffar

Dr. Muzaffar Abbas

PROFESSOR / DEAN FACULTY OF PHARMACY
PROFILE SUMMARY

Dr. Abbas completed the PhD degree in Neuropharmacology under Fulbright Scholarship Program from South Dakota State University, USA, in 2016. He has more than 15 years of teaching and research experience in the country and abroad. Dr. Abbas worked at different positions including Lecturer, Assistant Professor, Associate Professor, Professor, Head of Department and Dean. He has broad research interests in the areas of neuroscience, molecular pharmacology and neuropharmacology. His specific field of research focuses on drug discovery and development for neurological disorders include depression, memory, anxiety, opioid tolerance, opioid-induced paradoxical pain, addiction, neuropathic and neuroinflammatory pain in laboratory animal models. Dr. Abbas has supervised post-graduate research projects. He won NRPU-2021 from Higher Education of Pakistan (HEC) on diabetic neuropathy. Dr. Abbas is member of Board of Studies of different organizations across the country. He remained member of Society for Neuroscience (SFN), USA, American Society for Pharmacology and Experimental Therapeutics (ASPET), USA and American Pain Society (APS), USA. He is life time member of The Rho Chi Honor Society, South Dakota State University, USA

QUALIFICATION
PhD Pharmacology Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, USA 2016
MPhil Pharmacology Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan. 2009
B.Pharm Pharmaceutical Sciences Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan 2005
TEACHING EXPERIENCE
 Professor Capital University of Science and Technology (CUST), Islamabad Since – 2023
Associate Professor Capital University of Science and Technology (CUST), Islamabad 2018 – 2023
Assistant Professor Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 2017 – 2018
MANAGEMENT EXPERIENCE
Dean Faculty of Pharmacy, Capital University of Science & Technology, Islamabad Since – 2020
HoD Department of Pharmacy, Capital University of Science & Technology, Islamabad 2018 – 2020
HoD Department of Basic Medical Sciences, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 2017 – 2018
MEMBERSHIP OF PROFESSIONAL BODIES
PASBAN Member of Pakistan Society of Basic & Applied Neuroscience
AAPS Member of American association of Pharmaceutical Sciences
PPA Member of Pakistan Pharmacist Association (PPA)
SFN Member of Society for Neuroscience (SFN), USA.
Rho Chi Member of The Rho Chi Honor Society, South Dakota State University, USA
ASPET Member of American Society for Pharmacology and Experimental Therapeutics (ASPET), USA.
APS Member of American Pain Society (APS), USA
AAPM Member of American Academy of Pain Management, USA
RESEARCH AREAS / INTERESTS
1. Drug discovery
2. Neurological Disorders
3. Anxiety
4. Opioid Tolerance
RESEARCH SUPERVISION
1. PhD Synthesis, Characterization, In silico and Pharmacological Investigation of New Benzimidazole Derivatives against Neurodegenerative diseases
2. PhD Pharmacological Studies and Herbal Drug Development of Saussurea lappa, Saussurea heteromalla and Related Species.
3. MPhil Synthesis, Characterization and Pharmacological Evaluation of 5-Substituted Isoxazole-3-Carboxamides
4. MPhil Studies on Neuropharmacological Effects of methoxy benzylidine cyclopentanone
5. MPhil Hepatoprotective Effect of Ginkgo Biloba Extract against Methotrexate Induced Hepatotoxicity in Rats
6. MPhil Synthesis, Pharmacological Investigation and Molecular Docking Studies of 4-Thiazolidinone Derivatives
7. MPhil Neuropharmacological Investigation of Telmisartan against Opioid Dependence and its Correlation in Mesolimbic System
8. MPhil Pharmacological Investigation of Benzimidazole Derivatives against Opioid-Induced Paradoxical Pain in Animal Models
9. MPhil Neuropharmacological effects of 2-[(Pyrrolidin-1-yl)Methyl]-1H-Benzimidazole against Opioid Tolerance during Anticancer-Induced Neuropathic Pain
JOURNAL PUBLICATIONS
S. Alzarea, M. Abbas, P. J. Ronan, K. Lutfy, and S. Rahman, “The Effect of an α-7 Nicotinic Allosteric Modulator PNU120596 and NMDA Receptor Antagonist Memantine on Depressive-like Behavior Induced by LPS in Mice: The Involvement of Brain Microglia” Brain Sciences, vol.12, no.11, 1493, 2022.
H. Hussain, L. Rashan, U. Hassan, M. Abbas, F. L. Hakkim and I. R. Green, “Frankincense diterpenes as a bio-source for drug discovery”. Expert Opinion on Drug Discovery, vol. 17, no.5, pp. 513-529, 2022.
S. Qureshi, G. Ali1, M. Idrees, T. Muhammad, I. Kong, M. Abbas, M. I. A. Shah, S. Ahmad, R. D. E. Sewell and S. Ullah “Selected thiadiazine-thione derivatives attenuate neuroinflammation in chronic constriction injury induced neuropathy”. Frontiers in Molecular Neuroscience, vol. 14, 2021.
M. T. Khan, H. Nadeem, A. S. Sheikh, N. S. Malik, M. Rizwan, M. Imran, I. Javed, M. U. Munir, A. Khan, A. Syed and M. Abbas, “Amino acid derivatives of 2-Mercaptobenzimidazoles suppress cytokines at the site of inflammation and block gastric H+/K+ATPase”. Pakistan Journal of Pharmaceutical Sciences. vol. 34, no. 3, pp. 1157-1163, 2021.
M. Abbas, S. Alzarea, R. L. Papke, and S. Rahman, “Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-induced Allodynia and Hyperalgesia in a Mouse Model of Inflammatory Pain”. CNS & Neurological Disorders-Drug Targets, 2020 (ahead of print).
Z. Malik, M. Abbas, L. T. Al Kury, F. A. Shah, M. Alam, A. Khan, H. Nadeem, S. Alghamdi, M. U. K. Sahibzada, S. Li. “Thiazolidine derivatives attenuate carrageenan-induced inflammatory pain in mice”. Drug Design, Development and Therapy, vol. 15, pp. 369–384, 2021.
S. Akhtar, M Abbas, K. Naeem, M. Faheem, H. Nadeem, A. Mehmood. “Benzimidazole Derivative Ameliorates Opioid-mediated Tolerance during Anticancer-Induced Neuropathic Pain in mice”. Anti-Cancer Agents in Medicinal Chemistry, vol. 21, no. 3, pp. 365-371 2021.
N. Rehman, M. Rashida, A. Tokhi, Z. Ahmed, F. Subhan, M. Abbas, M. A. Arshid, and K. Rauf, “Analgesic and Antiallodynic Effects of 4-FluoroN-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain”. Drug Design, Development and Therapy, vol. 14, pp. 4511–4518. 2020.
N. Rehman, K. Esmaeilpour, S. Joushi, M. Abbas, M. Rashida e, K. Rauf, and Y. Masoumi-Ardakani, Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats. Biomedicine & Pharmacotherapy, vol. 131, pp. 110783. 2020.
M. T. Khan, H. Nadeem, A. Khan, M. Abbas, M. Arif, N. S. Malik, Z. Malik, and I. Javed, “Amino acid conjugates of 2-mercaptobenzimidazole provide better anti-inflammatory pharmacology and improved toxicity profile”. Drug Development Research, pp. 1–16, 2020.
N. Rehman, M. Abbas, M. Rashida, A. Tokhi, M. A. Arshid, M. S. Khan, I. Ahmad, and K. Rauf, “Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels”. Drug Design, Development and Therapy, vol. 14, pp. 3777–3786.2020.
M. S. Khan, W. Trenet, N. Xing, B. Sibley, M. Abbas, M. al-Rashida, K. Rauf and C. D. “Mandyam. “A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence”, International Journal of Molecular Sciences, vol. 21, no. 4411, 2020.
M. Imran, L. T. Al Kury, H. Nadeem, F. A. Shah, M. Abbas, S. Naz, A. Khan and S. Li, “Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration”, Biomolecules, vol. 10, no. 108, 2020.
M. Abbas, S. Alzarea, R. L. Papke, and S. Rahman, “The α7 nicotinic acetylcholine receptor positive allosteric modulator prevents lipopolysaccharide-induced allodynia, hyperalgesia and TNF-alpha in the hippocampus in mice”, Pharmacological Reports, vol. 71, no. 6, pp.1168-1176, 2019.
F. A. Shah, G. Liu, L. T. Al Kury, A. Zeb, P.O. Koh, M. Abbas, T. Li, X. Yang, F. Liu, Y. Jiang, and S. Li, “Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways”, Frontiers in Pharmacology, vol.10, pp.1-11, 2019.
Z. Idris, M. Abbas, H. Nadeem and A. Khan, “The benzimidazole derivatives, B1 (N-[(1H-Benzimidazol-2-yl)methyl]-4-methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)methoxy]phenyl}acetamide) attenuate morphine-induced paradoxical pain in mice”, Frontiers in Neuroscience, vol. 13, pp. 1-9, 2019.
H. Bibi, H. Nadeem, M. Abbas and M. Arif, “Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives”, BMC Chemistry, vol. 13, no. 6, pp.1-13, 2019.
T. Ahmed, A. Khan, M. Abbas, E. R. Filho, Z. Din and A. Khan, “Synthesis, characterization, molecular docking, analgesic, antiplatelet and anticoagulant effects of dibenzylidene ketone derivatives”, Chemistry Central Journal, vol. 12, no. 134, 2018.
M. Abbas, S. Alzarea, R. L. Papke, and S. Rahman, “The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice”, Drug Discoveries & Therapeutics, vol. 11, no. 4, pp. 206-211, 2017.
N. Islam, M. Abbas, and S. Rahman, “Neuropathic Pain and Lung Delivery of Nanoparticulate Drugs: An Emerging Novel Therapeutic Strategy”. CNS & Neurological Disorders-Drug Targets, vol. 16, pp. 303-310. 2017.
M. Abbas, and S. Rahman, “Effects of alpha-7 nicotinic acetylcholine receptor positive allosteric modulator on lipopolysaccharide-induced neuroinflammatory pain in mic”, European Journal of Pharmacology, vol. 783, pp. 85-91, 2016.
G. Ali, F. Subhan, M. Abbas, J. Zeb, M. Shahid, and R. D. E. Sewell, “A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin”. Naunyn-Schmiedeberg’s Archives of Pharmacology, vol. 388, no. 11, pp. 1129-1140, 2015.
M. Khan, F Subhan, A. Khan, M. Abbas, G. Ali, Khalid Rauf, and A. H. Gilani, “Nature cures nature: Hypericum perforatum attenuates physical withdrawal signs in opium dependent rats”, Pharmaceutical Biology, vol. 52, pp. 586-590. 2014.
K. Rauf, F. Subhan, M. Abbas, S. M. Ali, G. Ali, M. Ashfaq, and G. Abbas, “Inhibitory effect of bacopasides on spontaneous morphine withdrawal induced depression in mice”, Phytotherapy Research, vol. 28, pp. 937-939, 2014.
G. Ali, F. Subhan, N. Islam, I. Khan, K. Rauf, S. Ullah, M. Abbas, and A. Rauf, Input of Isosteric and Bioisosteric Approach in Drug Design. Journal of the Chemical Society of Pakistan, vol. 36, pp. 150-169, 2014.
H. Khan, M. Saeed, A. H.Gilani, H. M. Mehmood, N. U. Rehman, N. Muhammad, M. Abbas, and I. Haq, “Bronchodilator activity of aerial parts of Polygonatum verticillatum augmented by anti-inflammatory activity: attenuation of Ca²⁺ channels and lipoxygenase”, Phytotherapy Research, vol. 27, no. 9, pp. 1288-1292, 2013.
M. Abbas, F. Subhan, K. Rauf, I. Haq, and S. N. Mohani, “The involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri” Iranian Journal of Pharmacology & Therapeutics, vol. 11, no. 1, pp. 15-19, 2012
K. Rauf, F. Subhan, M. Abbas, I. Haq, G. Ali, and M. Ayaz, “Effect of acute and sub chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain” African Journal of Pharmacy and Pharmacology, Vol. 6, pp. 2767-2774, 2012.
M. Ismail, S. Rahman, A. zada, Roohullah, N. Muhammad, and M. Abbas, “Analgesic, anti GIT motility and toxicological activities of Pistaciai ntegerrima Stewart ex Brandis bark in mice”, Journal of Medicinal Plants Research, Vol. 6, no. 14, pp. 2827-2831, 2012.
K. Rauf, F. Subhan, M. Abbas, A. Badshah, I. Ullah, and S. Ullah, “Effect of bacopasides on acquisition and expression of morphine tolerance’, Phytomedicine. vol. 18, pp. 836-842. 2011.
M. Abbas, F. Subhan, K. Rauf, M. Khan, and S. N. Mohani. “The involvement of biogenic amines in the antidepressant effect of Bacopa monnieri”, PharmacologyOnline, vol. 1, pp. 112-123, 2011.
M. Abbas, F. Subhan, S. N. Mohani, K. Rauf, G. Ali, and M. Khan, “The involvement of opioidergic mechanisms in the activity of Bacopa monnieri extract and its toxicological studies”, African Journal of Pharmacy and Pharmacology, vol. 5, pp. 1120-1124. 2011.
S. Rahman, M. Ismail, M. Abbas, and N. Muhammad, “Study of antipyretic activity of Pistacia integerrima Stewart ex Brandis bark in Balb-C mice” Journal of Pharmacy Research, vol. 4, no. 12, pp. 4411-4412, 2011.
F. Subhan, M. Abbas, K. Rauf, and A. Baseer, “Anti GIT motility, toxicological and phytochemical studies on Bacopa monnieri”, PharmacologyOnline, vol. 3, pp. 907-950. 2010.
F. Subhan, M. Abbas, K. Rauf, M. Arfan, R. D. E. Sewell, and G. Ali, “The role of opioidergic mechanism in the activity of Bacopa monnieri extract against tonic and acute phasic pain modalities”, PharmacologyOnline, vol. 3, pp. 903-914, 2010.
CONFERENCE PUBLICATIONS
S. Rahman, and M. Abbas, “Effects of α7 nicotinic receptor positive allosteric modulator on sodium-potassium-chloride co-transporter 1 activation following lipopolysaccharide-induced neuroinflammatory pain in mice”, The FASEB Journal. Vol. 31, no. 1, pp. 812.2, 2017.
M. Abbas, and S. Rahman, “Brain alpha-7 nicotinic receptor positive allosteric modulator attenuates mechanical allodynia and hyperalgesia in a mouse model of neuroinflammatory pain” The Journal of Pain. Vol. 17, no. 4, pp. S75, 2016.
M. Abbas, and S. Rahman, “Antihyperalgesic and antiallodynic effects of 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c] quinoline-8 sulfonamide in an animal model of neuroinflammatory pain” The FASEB Journal. Vol. 30, pp. 927.1., 2016.
M. Abbas, and S. Rahman, “Effects of nicotinic acetylcholine receptor positive allosteric modulator on microglia activation following lipopolysaccharide-induced neuropathic pain” The FASEB Journal, vol. 29, pp. 770.14, 2015.
Shafiqur Rahman, Muzaffar Abbas. Effects of nicotinic acetylcholine receptor positive allosteric modulator in a neuropathic pain model. The FASEB Journal. (2014), 28, 661.10.

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