dr.shaukat

Dr. Shaukat Iqbal (PhD NKUA, Athens)

PROFESSOR
PROFILE SUMMARY

My research interests are G-2 Assays, (PCC) SCEs and Cytogenetic Techniques to determine Carcinogenicity & Genotoxicity from Chemical used in Agriculture, Medical Sciences and Environment, (e.g. Mutagens). Cytogenetic is also used for the detection for Leukemia, Genetic Disorders and Prenatal Diagnosis.

I loved to study, discuss and conduct research in biological sciences and to evaluate the root cause of genetic abnormalities. I have engaged the last 20 years of my life to get advance knowledge, to teach and to conduct research in the domain of genetics and Bio-chem y. I have published several papers in the different area of genetic anomalies including leukemia, radio-sensitivity, chromosomal aberrations, and several other genetics problems lead to severe human diseases.

As a professional, for the successful delivery of knowledge I, strongly believe on creative teaching, Innovative approaches and being interactive all the time during the lecture. In addition to that I have presented scientific base talk in several national and international conferences and symposia. I have introduced G2 Phase cytogenetic technique that was published in Oxford University in its Journal of Mutation.

Currently, we investigate Falcarinol Type polyacetylenes of Carrot inhibit proliferation and induce apoptosis in hepatocarinoma cell line, Hormonal Fluctuation of Postmenopausal Risk Leading to Breast Cancer in Pakistani population. Calcium dose involve in disrupting of cell cycle leading cancer in breast cells, Chromosomal Linkage with HIV patients in addition to that we are working on looking different aspect of Breast Cancer in Pakistani population.

QUALIFICATION
2nd Postdoctoral Cancer Cytogenetics Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, (LBCC, UNC-CH) NC.USA 2009
1st Postdoctoral Cancer Biology US Environmental Protection Agency , NHEERL, Cancer Biology Branch (Chemical Cytogenetics Section) RTP, NC, USA 2008
PhD Biochemistry and Molecular Biology National & Kapodestrain University of Athens & Cancer Cytogenetics & Environmental Hygiene Laboratory, NCSR “Demokritos, Athens 2004
M.Sc (Hon’s) Cytogenetics Sindh University, Pakistan 1998
B.Sc (Hon’s) Genetics Agricultural University Faisalabad, Pakistan 1993
TEACHING EXPERIENCE
Professor Capital University of Science and Technology (CUST), Islamabad Since – 2018
Associate Professor Capital University of Science and Technology (CUST), Islamabad 2015 – 2018
Associate Professor Qatar University 2014
Associate Professor National University of Science & Technology, Islamabad 2012 – 2013
Associate Professor Mohammad Ali Jinnah University, Islamabad 2007 – 2011
MANAGEMENT EXPERIENCE
Director VIS Directorate, Capital University of Science & Technology, Islamabad 2018 – 2021
Convener CUST university Discipline Committee 2017
Head Research of PG & UG Lab in CUST Since – 2016
Acting Chairman BUTUMS 2004 – 2005
Manager Animal Lab. House in NUST 2012 – 2013
Member NTS subject committee 2005 – 2007
Member Admission Subject Committee, NUST 2012 – 2013
Member Selection Board at NUST 2012 – 2013
HONORS & AWARDS
1. Selected for interview Fulbright Postdoc scholarship in 2014 but not availed due to Qatar University, Assignment
2. Students Feed Back: Gained in Qatar University 92. % PG & 78.6 % student’s feedback 2014 in advance bioinformatics Course.
3. Students Feed Back : in NUST 90.8% PG & 79.2 % students feedback
4. Best Faculty Performance Award Received Rs.30, 000 Cash from BUIETMS, ( 2005)
5. In 2007 HEC has awarded a Research Project under NRPU entitled “Genotoxicity testing of pesticides, plant protection products by means of pre mature chromosome condensation(PCC) in peripheral blood lymphocytes” Not Released yet, amount: PkR.3,703,920/-
6. Earned Excellent Professor award year09-10&10-11 in M.A. Jinnah University, Isb
7. Earned Scholarship from The Jackson Laboratory Medical
8. Scholarship for Experimental Models of Human Cancer
9. Earned Postdoc fellowship from HEC, Pakistan in 2008, for USA
10. Ten Times HEC Travel grants Received for paper presenting in International Conferences.
11. Several Lecture deliver as invited speaker in different DAI in Pakistan and abroad
12. Earned Scholarship for PhD from European Union DAC program via Greek Ministry of Education and Religious Affairs, Athens
13. Earned Scholarships for M. Sc (Hon’s)
14. Earned Scholarship for B. Sc (Hon’s) from Government of Baluchistan
RESEARCH AREAS / INTERESTS

1. Molecular Biology & Human Genetics;
2. Cancer Cytogenetics;
3. Comet Assay;
4. Micro-arrays Gene Expression & Data Analysis

JOURNAL PUBLICATIONS
1. S. Hussain, Y.-J. Xie, D. Li, S. I. Malik, J.-c. Hou, E. L.-H. Leung, and X.-X. Fan, “Current strategies against covid-19,” Chinese medicine, vol. 15, no. 1, pp. 1–12, 2020.
2. M. T. Khan, M. T. Zeb, H. Ahsan, A. Ahmed, A. Ali, K. Akhtar, S. I. Malik, Z. Cui, S. Ali, A. S. Khan et al., “Sars-cov-2 nucleocapsid and nsp3 binding: an in silico study,” Archives of Microbiology, pp. 1–8, 2020.
3. M. T. Khan, A. C. Kaushik, Q. ul ain Rana, S. I. Malik, A. S. Khan, D.-Q. Wei, W. Sajjad, S. Ahmad, S. Ali, M. Irfan et al., “Characterization and synthetic biology of lipase from bacillus amyloliquefaciens strain,” Archives of Microbiology, pp. 1–10, 2020.
4. M. T. Khan, S. Ali, M. T. Zeb, A. C. Kaushik, S. I. Malik, and D.-Q. Wei, “Gibbs free energy calculation of mutation in PNCA and RPSA associated with pyrazinamide resistance,” Frontiers in Molecular Biosciences, vol. 7, 2020.
5. M. T. Khan and S. I. Malik, “Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance,” Journal of Biomolecular Structure and Dynamics, pp. 1-15, 2019.
6. M. T. Khan, A. C. Kaushik, A. I. Bhatti, Y.-J. Zhang, S. Zhang, A. J. Wei, S. I. Malik, and D. Q. Wei, “Marine natural products and drug resistance in latent tuberculosis,” Marine Drugs, vol. 17, no. 10, p. 549, 2019.
7. A. U. Rehman, M. T. Khan, H. Liu, A. Wadood, S. I. Malik, and H.-F. Chen, “Ex¬ploring the pyrazinamide drug resistance mechanism of clinical mutants T370P and W403G in Ribosomal Protein S1 of mycobacterium tuberculosis,” Journal of chemical information and modeling, vol. 59, no. 4, pp. 1584-1597, 2019.
8. S. I. Malik, S. Ali, N. Masood, T. Nadeem, A. S. Khan, M. T. Afzal et al., “Pyrazi- namide resistance and mutations in pncA among isolates of Mycobacterium tubercu¬losis from Khyber Pakhtunkhwa, Pakistan,” BMC infectious diseases, vol. 19, no. 1, p. 116, 2019.
9. M. T. Khan, A. C. Kaushik, S. I. Malik, S. Ali, and D. Wei, “Artificial neural networks for prediction of tuberculosis disease,” Frontiers in microbiology, vol. 10, no. 1, p. 395, 2019.
10. M. T. Khan, S. I. Malik, A. I. Bhatti, S. Ali, A. S. Khan, M. T. Zeb, T. Nadeem, and S. Fazal, “Pyrazinamide-resistant mycobacterium tuberculosis isolates from Khyber Pakhtunkhwa and rpsA mutations,” Journal of Biological Regulators and Homeostatic Agents, vol. 32, no. 3, pp. 705–709, 2018.
11. M. T. Khan, S. I. Malik, S. Ali, A. Sheed Khan, T. Nadeem, M. T. Zeb, N. Masood, and M. T. Afzal, “Prevalence of pyrazinamide resistance in Khyber Pakhtunkhwa, Pakistan,” Microbial Drug Resistance, 2018
12. M. T. Khan, A. U. Rehaman, M. Junaid, S. I. Malik, and D.-Q. Wei, “Insight into novel clinical mutants of RpsA-S324F, E325K, and G341R of mycobacterium tuberculosis asso¬ciated with pyrazinamide resistance,” Computational and structural biotechnology journal, vol. 16, pp. 379–387, 2018.
13. M. Khan, S. Malik, A. Bhatti, S. Ali, A. Khan, M. Zeb, T. Nadeem, and S. Fazal, “Pyrazinamide-resistant mycobacterium tuberculosis isolates from khyber pakhtunkhwa and rpsA mutations.,” Journal of biological regulators and homeostatic agents, vol. 32, no. 3, p. 705, 2018.
14. M. Anum, S. I. Malik, and K. A. Malik, “Proteome mining for the identification of putative drug targets for human pathogen clostridium tetani,” Current Bioinformatics, 2018.
15. A. Munir, S. I. Malik, and K. A. Malik, “De-novo ligand design against mutated huntington gene by ligand-based pharmacophore modeling approach.,” Current computer-aided drug design, 2018.
16. M. N. Shahwani, S. Nisar, A. Aleem, M. Panezai, S. Afridi, and S. I. Malik, “Ampli¬fication of mitochondrial DNA for detection of plasmodiumvivax in Balochistan,” The Journal of the Pakistan Medical Association, vol. 67, no. 5, p. 677, 2017.
17. S. Kanwal, S. Nishat, M. I. Khan, S. I. Malik, and K. Akhtar, “Comparative homology modeling of human rhodopsin with several templates of bovine rhodopsin,” African Journal of Biotechnology, vol. 11, no. 2, pp. 466–473, 2012.
18. S. Sameen, Z. Khalid, and S. I. Malik, “Role of pyruvate dehydrogenase kinases (PDKs) and their respective microRNAs in human ovarian cancer,” Journal of Medical Genetics and Genomics, vol. 3, no. 7, pp. 115–121, 2011.
19. S. Malik and S. Khan, “Cancer prevention through employ of appropriate diet in daily schedule,” Journal of Cancer Science & Therapy, vol. 15, p. 17, 2011.
20. A. D. Kligerman, S. I. Malik, and J. A. Campbell, “Cytogenetic insights into DNA damage and repair of lesions induced by a monomethylated trivalent arsenical,” Muta¬tion Research/Genetic Toxicology and Environmental Mutagenesis, vol. 695, no. 1, pp. 2–8, 2010.
CONFERENCE PUBLICATIONS
1. BMS-CCADD-2018-56 ACCEPTED :Title: De-Novo Ligand Design Against Mutated Huntington Gene based on Ligand Based Pharmacophore Modeling Approach , A. Munir, Shaukat I. Malik , K Akhtar
2. BMS-CBIO, 2018-127 accepted “Proteome mining for the identification of putative drug targets for human pathogen clostridium titanium. A. Munir, Shaukat I. Malik ,K Akhtar
3. Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan. M. Tahir Khan, ; Shaukat I. Malik,; Sajid Ali, ; N Masood, T. Nadeem, Anwar S Khan, ; M. Tanvir Afzal, ACCEPTED in BMC Infectious Diseases
4. Prevalence of Pyrazinamide Resistance in Khyber Pakhtunkhwa, Pakistan. M.Tahir Khan, Shaukat I. Malik, Sajid Ali, Anwar S. Khan, T Nadeem, M. Tariq Zeb, N. Masood, M.T. Afzal. Microbial Drug Resist. 201827. doi:10.1089.2017.0234
5. Manuscript entitled: Elastic network modelling of E7 protein of Human Papilloma Virus and prediction of host proteins affected by E7. VIRUS_2018_151: Corresponding author: Mrs Rabbiah Malik, : Mrs Fakhra Nazir, Shaukat Malik, DSahar Fazal, Mukhtar Ullah, ,Aamer Bhatti
6. “Pyrazinamide resistance and Mutations L19R, R140H and E144K in pncA of Mycobacterium tuberculosis” by Khan, Muhammad; Junaid, muhammad; Malik, Shaukat; Wei, Dong. Submitted manuscript ID number JCB-18-1370.
7. Sameen, S.; Khalid, Z.; Malik, S.I. In Silico Mining of RAS Gene Family Expression Data in Human Thyroid Cancer, Published in IEEE Explore 2011.

Other Members