dr.maryam

Dr. Syeda Marriam Bakhtiar (PhD QAU, Islamabad)

ASSISTANT PROFESSOR
PROFILE SUMMARY

My research uses Molecular Genetics and computational biology approaches to understand the complexities of the inherited genetic diseases, their characterization at molecular level and strategies for control and prevention. I am also interested in infectious diseases, causative microbes and corresponding immune responses by the host. My research group also works on application of Bioinformatics and Computational biology approaches to analyze and interpret the vast amount of genomic data available on public databases and utilization of this data for its full potential to progress our scientific understanding focused on human health and disease.

QUALIFICATION
PhD Human Molecular Genetics National Institute of Biotechnology and Genetic Engineering, Faisalabad. Quaid-i-Azam University 2014
MSc Biochemistry University of Arid Agriculture, Rawalpindi 2005
TEACHING EXPERIENCE
Visiting Faculty Quaid i Azam University Islamabad 2013 – 2013
INDUSTRIAL EXPERIENCE
Research Assistant Department of Bioinformatics, Federal University of Minas Gerais, Brasil 2012 – 2012
Research Assistant Wilhelm Johansen Center for Functional Genomics WJC, University of Copenhagen, Copenhagen Denmark 2009 – 2010
MANAGEMENT EXPERIENCE
Member Quality Assurance Committee 2016
Member University Health and Safety Commitee 2017
Coordinator Final Year Projects 2016 – 2017
Coordinator MS Thesis 2016-2017
Coordinator Internship 2016 – 2018
Departmental Coordinator Volunteer in service 2016 – 2018
Convener Departmental Team for BS Biotechnology 2018
Convener Convener Curriculum Review Committee 2017 – 2018
MEMBERSHIP OF PROFESSIONAL BODIES
Member American Society of Microbiology
HONORS & AWARDS
1 European Molecular Biology Organization ( EMBO) short Term fellowship to Denmark, 2011)
2 HEC Indigenous PhD Scholarship 2006
RESEARCH AREAS / INTERESTS
  1. My research interests include molecular understanding of inherited diseases/disorders and other infectious diseases more prevalent in Pakistan;
  2. I am implementing integrated Molecular Genetics and Genomics approaches to understand the complexities of the inherited genetic diseases, their characterization at the molecular level and strategies for control and prevention.;
  3. Similarly, in infectious diseases, I am particularly interested in pathogen-host interaction in analyzing the genomic data (sequencing).;
  4. My research group also employing Bioinformatics and Computational biology approaches to analyze and interpret the vast amount of genomic data available on public databases and utilization of this data for its full potential to progress our scientific understanding in human health and disease.
RESEARCH SUPERVISION
1. MS Subtractive Genomics Analysis to Develop Treatment Stretegies for Streptococcus pneumonia
2. MS Networks and pathways analysis of bacteriocin producing gene in selected lactic acid bacterial species
3. MS Prevalence of Inflammatory Disorders in Obese and Non- Obese Subjects of Kahuta Region
4. MS Prevalence and Risk Factor Associated with Blood Borne Hepatitis in Kahuta Region of Pakistan
5. MS Impact Estimation of Inflammatory Genes IL-6, TNF-Alpha and ACE on Diabetes and Obesity as Comorbidity Of CAD
6. MS Genetic Heterogeneity in Pakistani Obese Individuals
7. MS Prevalence and Functional Analysis of Commonly Reported SNPs in Pakistani Obese Kindreds
8. MS Prevalence of Helicobacter Pylori in Obese Subjects of Rawalpindi
9. MS Prevalence of Genetic and Non- Genetic Risk Factors for Diabetes Among Obese Individuals
10. MS Genome Mining and Pathway Analysis of Core Bacteriocin Produced by Selected Lactic Acid Bacteria
JOURNAL PUBLICATIONS
1. Amjad Ali, Syeda Marriam Bakhtiar and Vasco Azevedo, “Autism Spectrum Disorders (ASD): From Diagnosis to Management (invited article)”, J Mol Genet Med, 2015
2. Amjad Ali, Anam Naz, Siomar C Soares, Bakhtiar SM, Sandeep T, Hassan S, Hanan F, Ramos R, Pereira U, Barh D, Figueiredo HP, Ussery DW, Miyoshi A, Silva A Vasco Azevedo, “Pangenome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets”, Biomed Res Int, 2015
3. Amjad Ali, Anam Naz, Siomar de Castro Soares, Bakhtiar M, Sandeep Tiwari, Shah Hassan, Fazal Hanan, Rommel Ramos, Ulisses Pereira, Debmalya Barh, Henrique César Pereira Figueiredo, David W. Ussery, Anderson Miyoshi, Artur Silva, Vasco Azevedo, “Pangenome Analysis of Human Gastric Pathogen H. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets “, BioMed Research International , (Article in Press)2014
4. Bakhtiar SM, Ali A, Baig SM, Barh D, Miyoshi A, Azevedo V. , “Mini Review Identifying human disease genes: advances in molecular genetics and computational approaches.”, Genet Mol Res. , No: 13, Pages: 5073-87, 2014
5. Barh D, Gupta K, Jain N, Khatri G, León-Sicairos N, Canizalez-Roman A, Tiwari S, Verma A, Rahangdale S, Shah Hassan S, dos Santos AR, Ali A, Guimarães LC, Thiago Jucá Ramos R, Devarapalli P, Barve N, Bakhtiar S.M, Kumavath R, Ghosh P, Miyoshi A, Silva A, Kumar A, Misra AN, Blum K, Baumbach J, Azevedo V., “Conserved host-pathogen PPIs. Globally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds”, Integr Biol (Camb)., 2013
6. Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimarães LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V, “The Pan-Genome of the Animal Pathogen Corynebacterium pseudotuberculosis Reveals Differences in Genome Plasticity between the Biovar ovis and equi Strains.”, PLoS One, 2013
7. AR Carneiro, RTJ Ramos, H Dall’Agnol, AC Pinto, Franco LC DA, A Ali, SS Hassan, CIP Nunes, MS Barbosa, KK Fiaux, FF Aburjaile, EGV Barbosa, SM Bakhtiar, D Vilela, MA Cregger, CW Schadt, NG McDowell, WT Pockman, AT Classen. , “Further Readings in Geomicrobiology”, Geomicrobiology Journal , 2013
8. Ali A, Soares SC, Barbosa E, Santos AR, Barh D, Bakhtiar SM, Hassan SS, Ussery DW, Silva A, Miyoshi A, Azevedo V , “Microbial Comparative Genomics: An Overview of Tools and Insights Into The Genus Corynebacterium. “, Journal of Bacteriology & Parasitology, 2013
9. Ulisses de Pádua Pereira, Anderson Rodrigues dos Santos, Syed Shah Hassan, Flávia Figueira Aburjaile, Siomar de Castro Soares, Rommel Thiago Jucá Ramos, Adriana Ribeiro Carneiro, Luís Carlos Guimarães, Sintia Silva de Almeida, Carlos Augusto Almeida Diniz, Maria Silvanira Barbosa, Pablo Gomes de Sá, Amjad Ali, Syeda Marriam Bakhtiar, Fernanda Alves Dorella, Adhemar Zerlotini, Flávio Marcos Gomes Araújo, Laura Rabelo Leite, Guilherme Oliveira, Anderson Miyoshi, Artur Silva, Vasco Azevedo, Henrique César Pereira Figueiredo, “Complete genome sequence of Streptococcus agalactiae strain SA20-06, a fish pathogen associated to meningoencephalitis outbreaks”, Stand. Genomic Sci. , 2013
10. Sajid Hussain M, Bakhtiar SM, Farooq M, Anjum I, Janzen E, Reza Toliat M, Eiberg H, Kjaer K, Tommerup N, Noegel A, Nürnberg P, Baig S, Hansen L, “Genetic heterogeneity in Pakistani microcephaly families”, Clin Genet, No: 5, Pages: 446-51, 2013
11. Bakhtiar SM, Leblanc JG, Salvucci E, Ali A, Martin R, Langella P, Chatel JM, Miyoshi A, Bermúdez-Humarán LG, Azevedo V, “. Implications of the human microbiome in Inflammatory Bowel Diseases.”, FEMS Microbiol Lett., No: 1, Pages: 10-7, 2013
12. Mahmood Baig S, Sabih D, Rahim MK, Azhar A, Tariq M, Sajid Hussain M, Saqlan Naqvi SM, Raja GK, Khan TN, Jameel M, Iram Z, Noor S, Baig UR, Qureshi JA, Baig SA, Bakhtiar SM., “ß-Thalassemia in Pakistan: a pilot program on prenatal diagnosis in Multan. “, J Pediatr Hematol Oncol., 2012
13. Lopes T, Silva A, Thiago R, Carneiro A, Dorella FA, Rocha FS, dos Santos AR, Lima AR, Guimarães LC, Barbosa EG, Ribeiro D, Fiaux KK, Diniz CA, de Abreu VA, de Almeida SS, Hassan SS, Ali A, Bakhtiar SM, Aburjaile FF, Pinto AC, Soares Sde C, Pereira Ude P, Schneider MP, Miyoshi A, Edman J, Spier S, Azevedo V, “Complete genome sequence of Corynebacterium pseudotuberculosis strain Cp267, isolated from a llama.”, J Bacteriol. , 2012
14. Pethick FE, Lainson AF, Yaga R, Flockhart A, Smith DG, Donachie W, Cerdeira LT, Silva A, Bol E, Lopes TS, Barbosa MS, Pinto AC, Dos Santos AR, Soares SC, Almeida SS, Guimaraes LC, Aburjaile FF, Abreu VA, Ribeiro D, Fiaux KK, Diniz CA, Barbosa EG, Pereira UP, Hassan SS, Ali A, Bakhtiar SM, Dorella FA, Carneiro AR, Ramos RT, Rocha FS, Schneider MP, Miyoshi A, Azevedo V, Fontaine MC, “Complete genome sequence of Corynebacterium pseudotuberculosis strain 1/06-A, isolated from a horse in North America.”, J Bacteriol., 2012
15. Pethick FE, Lainson AF, Yaga R, Flockhart A, Smith DG, Donachie W, Cerdeira LT, Silva A, Bol E, Lopes TS, Barbosa MS, Pinto AC, dos Santos AR, Soares SC, Almeida SS, Guimaraes LC, Aburjaile FF, Abreu VA, Ribeiro D, Fiaux KK, Diniz CA, Barbosa EG, Pereira UP, Hassan SS, Ali A, Bakhtiar SM, Dorella FA, Carneiro AR, Ramos RT, Rocha FS, Schneider MP, Miyoshi A, Azevedo V, Fontaine MC, “Complete genome sequences of Corynebacterium pseudotuberculosis strains 3/99-5 and 42/02-A, isolated from sheep in Scotland and Australia, respectively.”, J Bacteriol., 2012
16. Ali A, Soares SC, Santos AR, Guimarães LC, Barbosa E, Almeida SS, Abreu VA, Carneiro AR, Ramos RT, Bakhtiar SM, Hassan SS, Ussery DW, On S, Silva A, Schneider MP, Lage AP, Miyoshi A, Azevedo V, “Campylobacter fetus subspecies: comparative genomics and prediction of potential virulence targets. “, Gene. , 2012
17. Hassan SS, Schneider MP, Ramos RT, Carneiro AR, Ranieri A, Guimarães LC, Ali A, Bakhtiar SM, Pereira Ude P, Dos Santos AR, Soares Sde C, Dorella F, Pinto AC, Ribeiro D, Barbosa MS, Almeida S, Abreu V, Aburjaile F, Fiaux K, Barbosa E, Diniz C, Rocha FS, Saxena R, Tiwari S, Zambare V, Ghosh P, Pacheco LG, Dowson CG, Kumar A, Barh D, Miyoshi A, Azevedo V, Silva A., “Whole-Genome Sequence of Corynebacterium pseudotuberculosis Strain Cp162, Isolated from Camel”, J Bacteriol., 2012
18. Carneiro AR, Ramos RT, Dall’agnol H, Pinto AC, de Castro Soares S, Santos AR, Guimarães LC, Almeida SS, Baraúna RA, das Graças DA, Franco LC, Ali A, Hassan SS, Nunes CI, Barbosa MS, Fiaux KK, Aburjaile FF, Barbosa EG, Bakhtiar SM, Vilela D, Nóbrega F, Dos Santos AL, Carepo MS, Azevedo V, Schneider MP, Pellizari VH, Silva A, “Genome Sequence of Exiguobacterium antarcticum B7, Isolated from a Biofilm in Ginger Lake, King George Island, Antarctica”, J Bacteriol., 2012
19. Soares SC, Trost E, Ramos RT, Carneiro AR, Santos AR, Pinto AC, Barbosa E, Aburjaile F, Ali A, Diniz CA, Hassan SS, Fiaux K, Guimarães LC, Bakhtiar SM, Pereira U, Almeida SS, Abreu VA, Rocha FS, Dorella FA, Miyoshi A, Silva A, Azevedo V, Tauch A., “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production.”, J Biotechnol., 2012
20. Sadia Nawaz, Muhammad Tariq, Aysha Azhar, Mahmood Rasool, Syeda Marriam Bakhtiar, Ilyas Ahmad, Shoaib ur Rehman, Muhammad Jameel, Tahir Naeem Khan, Shehla Anjum Baig, Joakim Klar, Niklas Dahl, Shahid Mahmood Baig. , “Report of a recurrent mutation in ARS (component B) gene with severe Mal de Meleda in a large consanguineous Pakistani family”, Pak J Med Sci , 2011
21. Muhammad Kashif Rahim, Durr-e-Sabih, Shahid Mehmood Baig, Ayesha Azhar and Marriam Bakhtiar., “Prenatal Diagnosis of Beta- Thalassemia at MINAR, Multan”, Nishtar Medical Journal, 2009
22. Farooq, M., Troelsen, J.T., Boyd, M., Hansen, L., Eiberg, H., Hussain, M.S., Rehman, U.R., Azhar, A., Ali, A., Bakhtiar, SM., Tommerup, N., Baig, S.M. and Klaus, W.K., “Preaxial polydactyly/triphalangeal thumb is associated with changed transcription factor binding affinity in a family with a novel point mutation in the long range cis-regulatory element ZRS.”, Eur J Hum Genet , 2009
22. Hammad Safdar, Rashid Ali, Syeda Marriam Bakhtiar. Implementation of Mathematical Models for HCV Infection.J. Appl. Environ. Biol. Sci. 2016 6(2S): 109-113
23. Hina Aslam Butt, Syeda Marriam Bakhtiar. Identification and Classification of bacterial Auto transporters . Jurnal Teknologi (Sciences & Engineering) 78: 4–3 (2016) 47–51
24. Shifa Tariq Ashraf, Syeda Marriam Bakhtiar. Exploring the Protein Interaction Related to Hepatitus C Virus. NUST J. Nat Sci. 3:1 (2015)13-18
CONFERENCE PUBLICATIONS
1. Faiz Q., Zarif S., Nadeem A., Ali A., Bakhtiar S.M., “Graphical Representation of Biological Regulatory Network Involved In Wnt Signaling.”, 1st Student Research Conference on Biological sciences, NIBGE, Faislabad, 2014
2. Gulshad N., Azam S., , Nadeem A., Bakhtiar S.M, “Clinical Biomarker Based Prediction of Liver Carcinoma”, 1st Student Research Conference on Biological sciences, NIBGE, Faislabad. , 2014
3. Zeb S., Bakhtiar S.M, “Genome Mining and Phylogenetic analysis for Bacteriocin produce by lactobacillus and lactococcus”, 1st Student Research Conference on Biological sciences, NIBGE, Faislabad. , 2014
4. Ajaz H., Nadeem M., Nadeem A., Taj I.A., Bakhtiar S.M., “Gel Automation for Analysis of Multiplex-PCR visualization for the diagnosis of ß-thalassemia.”, 1st Student Research Conference on Biological sciences, NIBGE, Faislabad. , 2014
5. Safdar H, Gulshad N, Azam S, Zeb S, Bakhtiar SM, “Identification of Biomarkers in hepatocellular carcinoma by using clinical and computational techniques.”, 2nd conference on emerging trends in bioinformatics and computational biology. MAJU. Islamabad, 2014
6. Zarif S, Malik Q, Vaqar S, Ajaz H, Nadeem M, Bakhtiar SM, “Protein structure analysis of most common SNP in ASPM: Gene responsible ofr microcephaly.”, 2nd conference on emerging trends in bioinformatics and computational biology. MAJU. Islamabad, 2014
7. Zeb S, Vaqar S, Bakhtiar SM,. , “Bacteriocin production and Niche specific evolution of Lactococcus lactis sub sp cremoris: computational insight into genome. “, 2nd conference on emerging trends in bioinformatics and computational biology. MAJU. Islamabad. , 2014
8. Zeb S, Vaqar S, Bakhtiar SM, “Bacteriocin production and Niche specific evolution of Lactococcus lactis sub sp cremoris: computational insight into genome. “, 2nd conference on emerging trends in bioinformatics and computational biology. MAJU. Islamabad. , 2014
9. Bakhtiar, M., Azhar, A., Tariq, M., Ali, A., Baig, S.M., “Establishemnt of first trimester prenatal diagnosis through chorionic villus sampling. “, Pakistan Society of Haematology, 11th Annual Haematology Conference,Peshawar, 2011
10. Bakhtiar, S.M., Hansen L., Baig, S.M., Eiberg, H., Lind-Thomson, A., Tommerup, N, “Genetics of Stuttering.”, 7th Annual Meeting, ICMM, Cell Biology Cluster and Postgraduate School, LO Skolen, Helsingor, Denmark., 2011
11. Rehman, S., Hansen, L., Bakhtiar, S.M., Tariq, M., Ahmed, I., Tpmmerup, N., Baig, S.M., “Molecular genetics of autosomal recessive mental retardation (ARMR) in consanguineous Pakistani families.”, European Society of Human Genetics (ESHG) Conference, Gothenburg, Sweden, 2010
12. Tariq, M., Azhar, A., Klar, J., Ahmad, I., Bakhtiar, S.M., Baig, S.M., Dahl, N. , “Isolated autosomal recessive hypotrichosis in Pakistan caused by P2RY5 and LIPH gene mutations.”, European Society of Human Genetics (ESHG) Conference, Gothenburg, Sweden, 2010
13. Bakhtiar, M., Azhar, A., Tariq, M., Ali, A., Baig, S.M., “Establishemnt of first trimester prenatal diagnosis through chorionic villus sampling. “, Pakistan Society of Haematology, 11th Annual Haematology Conference,Peshawar, 2009
14. Bakhtiar, S.M., Sabih D., Ibrahim, K., Azhar, A., Tariq, M., Hussain, M.S., Baig, S.M, “First trimester prenatal diagnosis of ß –Thalassemia in Pakistan”, . 59th Annual meeting of American Society of Human Genetics (ASHG), Honolulu, , 2009
15. Ahmad, I., Tariq, M., Ali, A., Bakhtiar, M., Azhar, A., Baig, S.M. , “Inherited alopecia and ectodermal dysplasia in Pakistani Kindreds. “, European Society of Human Genetics (ESHG) Conference May 31 – June 3, 2008, Barcelona Spain, 2008
16. Rasool, M., Nawaz, S., Azhar, A., Ahmad,I. Ali. A,, Tariq,M., Bakhtiar,M.,., Baig,S.M., “Molecular genetic analysis of inherited skin disorders in consanguineous Pakistani families. “, 2nd National Conference on Health Biotechnology, 27-28 May, 2008. Pakistan Academy of Science, Islamabad. , 2008
17. Baig, S.M., Nawaz, S., Azhar, A., Tariq, M., Bakhtiar, M., Ali, A., Rasool, M., “Molecular genetic analysis of inherited skin disorders in consanguineous Pakistani families”, 2nd National Conference on Health Biotechnology, 27-28 May, 2008. National Commission on Biotechnology, Islamabad, Pakistan., 2008
18. Ahmad, I., Rehman, S., Tariq, M., Ali, A., Bakhtiar, M., Azhar, A., Baig, S.M., “Inherited alopecia and ectodermal dysplasia in families from Southern Punjab and Northern Pakistan. “, International conference on Medical and Community Genetics,Chandigarh, India., 2008
19. Ahmad, I., Rasool, M., Ali, A., Bakhtiar, M., Baig, S.M., “Linkage study of Ectodermal Dysplasias in Pakistani Inbred Families.”, 58th annual meeting Philadelphia, Pennsylvania, ASHG, 2008
20. Baig SM, Bakhtiar, M, “Controlling monogenic disorders through cascade testing, prenatal diagnosis and genetic counseling in a highly consanguineous population.”, . 3rd international workshop on “Genetics, history and public understanding” Barcelona Spain , 2008
21. Baig, S.M., Bakhtiar, M, “Controlling Monogenic Disorders through Cascade Testing, Prenatal Diagnosis and Genetic Counseling in a Highly Consanguineous Population.”, 9th PSBMB conference,University of Arid Agriculture, Rawalpindi, Pakistan., 2008

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